Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation (Q34898927)

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24 February 2020

title

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation (English)

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24 February 2020

1

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24 February 2020

William J Israelsen

4

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24 February 2020

Eran R Andrechek

20

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24 February 2020

Sarah-maria Fendt

21

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Scott R Manalis

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24 February 2020

Gregory Stephanopoulos

17

object named as

Gregory Stephanopoulos

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24 February 2020

author name string

Vinayak Muralidhar

2

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Aaron M Hosios

3

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24 February 2020

Dan Y Gui

5

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24 February 2020

Lauren Newhouse

6

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24 February 2020

Martin Ogrodzinski

7

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24 February 2020

Vivian Hecht

8

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24 February 2020

Kali Xu

9

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24 February 2020

Paula N Marín Acevedo

10

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Daniel P Hollern

11

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24 February 2020

Gary Bellinger

12

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24 February 2020

Talya L Dayton

13

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24 February 2020

Stefan Christen

14

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24 February 2020

Ilaria Elia

15

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24 February 2020

Anh T Dinh

16

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24 February 2020

Michael B Yaffe

19

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24 February 2020

Matthew G Vander Heiden

22

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publication date

4 December 2014

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24 February 2020

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24 February 2020

volume

57

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24 February 2020

page(s)

95-107

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24 February 2020

issue

1

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describes a project that uses

24 February 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.

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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells.

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

8 July 2018

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SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions

8 July 2018

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

8 July 2018

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PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis

8 July 2018

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Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase

8 July 2018

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Myoblast fusion: lessons from flies and mice

8 July 2018

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

8 July 2018

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Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

8 July 2018

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8 July 2018

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Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction Point from a Nutrient-Sensing Cell Growth Checkpoint(s)

8 July 2018

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Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth.

8 July 2018

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Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

8 July 2018

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8 July 2018

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Pyruvate kinase M2 is a phosphotyrosine-binding protein

8 July 2018

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8 July 2018

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Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions

8 July 2018

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8 July 2018

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Nutrient regulation of cell cycle progression

8 July 2018

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Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines

8 July 2018

1 reference

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Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats

8 July 2018

1 reference

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Regulation of pyruvate kinase M gene expression

8 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

8 July 2018

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Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines

8 July 2018

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8 July 2018

The fusion of myoblasts

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The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters.

8 July 2018

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A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity

8 July 2018

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Interactions between deoxyribonucleotide and DNA synthesis

8 July 2018

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The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing

8 July 2018

1 reference

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The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

8 July 2018

1 reference

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Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine

8 July 2018

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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

8 July 2018

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Coordination of growth with cell division in the yeast Saccharomyces cerevisiae

8 July 2018

1 reference

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Enhancement of the therapeutic effectiveness of methotrexate and protection of normal proliferating tissues with purines and pyrimidines

8 July 2018

1 reference

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Conversion of 3T3 fibroblasts into adipose cells: triggering of differentiation by prostaglandin F2alpha and 1-methyl-3-isobutyl xanthine

8 July 2018

1 reference

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Turnover Rates of Hexokinase I, Phosphofructokinase, Pyruvate Kinase and Creatine Kinase in Slow-Twitch Soleus Muscle and Heart of the Rabbit

8 July 2018

1 reference

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Alanine inhibition of pyruvate kinase in gliomas and meningiomas. A diagnostic tool in surgery for gliomas?

8 July 2018

1 reference

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Allosteric regulation of PKM2 allows cellular adaptation to different physiological states

8 July 2018

1 reference

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An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis.

26 October 2018

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Weighing of biomolecules, single cells and single nanoparticles in fluid.

26 October 2018

1 reference

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Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes.

26 October 2018

1 reference

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Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.

26 October 2018

1 reference

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Drosophila S6 kinase: a regulator of cell size

26 October 2018

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Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline-deficient/DL-ethionine-supplemented diet.

26 October 2018

1 reference

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Effects of guanine nucleotide depletion on cell cycle progression in human T lymphocytes

26 October 2018

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12 December 2020

Pyruvate kinase isozymes from rat

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[Alteration of isozyme gene expression during cell differentiation and oncogenesis]

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Cytochemical detection of a senescence-associated beta-galactosidase in endothelial and smooth muscle cells from human and rabbit blood vessels

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The mechanism of action of methotrexate in cultured L5178Y leukemia cells

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Cellular senescence in the pathogenesis of benign prostatic hyperplasia

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Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells

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Immunohistological demonstration of pyruvate kinase isoenzyme type L in rat with monoclonal antibodies

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12 December 2020

Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism

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12 December 2020

10.1016/J.MOLCEL.2014.10.027

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482511%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482511%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25482511%20AND%20SRC:MED&resulttype=core&format=json