How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? (Q36879036)

16 August 2017

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title

How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression? (English)

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16 August 2017

3

Strasser A

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16 August 2017

Olsson A

1

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PubMed ID

17627286

16 August 2017

Manzl C

series ordinal

2

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PubMed ID

17627286

16 August 2017

Villunger A

series ordinal

4

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16 August 2017

13 July 2007

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Cell Death & Differentiation

16 August 2017

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16 August 2017

14

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16 August 2017

1561-1575

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16 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4402196

16 August 2017

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bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

21 January 2018

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BID regulation by p53 contributes to chemosensitivity

21 January 2018

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Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria

21 January 2018

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Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death

21 January 2018

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21 January 2018

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Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

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Proapoptotic BID is an ATM effector in the DNA-damage response

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A role for proapoptotic BID in the DNA-damage response

21 January 2018

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The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

21 January 2018

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PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

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Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

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PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

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Integral role of Noxa in p53-mediated apoptotic response

21 January 2018

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

21 January 2018

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Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

21 January 2018

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Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription

21 January 2018

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

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p53 has a direct apoptogenic role at the mitochondria

21 January 2018

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Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

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The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage

21 January 2018

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Post-translational modification of p53 in tumorigenesis

21 January 2018

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Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

21 January 2018

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The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

21 January 2018

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Functional regulation of p73 and p63: development and cancer

21 January 2018

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p53 isoforms can regulate p53 transcriptional activity.

21 January 2018

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Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule

21 January 2018

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DeltaNp53 or p44: priming the p53 pump.

21 January 2018

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A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Modulation of mammalian life span by the short isoform of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Probing p53 biological functions through the use of genetically engineered mouse models

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Phosphorylation of serine 18 regulates distinct p53 functions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Mutation of mouse p53 Ser23 and the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

21 January 2018

1 reference

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A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p53 ubiquitination: Mdm2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

SUMO-1 modification activates the transcriptional response of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

MDM2-ARF complex regulates p53 sumoylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Functional analysis and intracellular localization of p53 modified by SUMO-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The Proline Repeat Domain of p53 Binds Directly to the Transcriptional Coactivator p300 and Allosterically Controls DNA-Dependent Acetylation of p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Binding and modulation of p53 by p300/CBP coactivators

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

High-frequency developmental abnormalities in p53-deficient mice.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Phosphorylation of murine p53 at ser-18 regulates the p53 responses to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

21 January 2018

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ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

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Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Induction and endoplasmic reticulum location of BIK/NBK in response to apoptotic signaling by E1A and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Identification and characterization of a novel p300-mediated p53 acetylation site, lysine 305.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Synergistic activation of transcription by CBP and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Deacetylation of p53 modulates its effect on cell growth and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Regulation of p53 activity through lysine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Repression of p53 activity by Smyd2-mediated methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

High metastatic potential in mice inheriting a targeted p53 missense mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

Factors governing loss and rescue of DNA binding upon single and double mutations in the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

GADD45-induced cell cycle G2-M arrest associates with altered subcellular distribution of cyclin B1 and is independent of p38 kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Negative feedback regulation of wild-type p53 biosynthesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4402196

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4402196

1 reference

16 August 2017

1 reference

PubMed ID

17627286