Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription (Q44687763)

5 December 2017

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription (English)

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5 December 2017

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5 December 2017

Douglas R Green

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author name string

Ulrich Maurer

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2

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PubMed ID

14667504

5 December 2017

Martin Schuler

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4

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5 December 2017

1 November 2003

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5 December 2017

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5 December 2017

4

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5 December 2017

371-381

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5 December 2017

5

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The Bcl-2 protein family: arbiters of cell survival

5 December 2017

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Cell surface trafficking of Fas: a rapid mechanism of p53-mediated apoptosis.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Caspases induce cytochrome c release from mitochondria by activating cytosolic factors

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis reveals a nuclear:cytoplasmic shuttling defect

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Essential role for caspase-8 in transcription-independent apoptosis triggered by p53

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Pharmacological rescue of mutant p53 conformation and function

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

The MDM2 RING-finger domain is required to promote p53 nuclear export

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Apoptotic pathways: paper wraps stone blunts scissors

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

A matter of life and death

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

BH3-Only proteins-essential initiators of apoptotic cell death

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53, the cellular gatekeeper for growth and division

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Regulation and activation of p53 and its family members

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53 has a direct apoptogenic role at the mitochondria

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Apaf-1 is a transcriptional target for E2F and p53

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

PUMA, a novel proapoptotic gene, is induced by p53

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Parc: a cytoplasmic anchor for p53.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

The IARC TP53 database: new online mutation analysis and recommendations to users

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Regulation of the p53 tumor suppressor protein

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Essential role for p53-mediated transcription in E1A-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

BAX-dependent transport of cytochrome c reconstituted in pure liposomes

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

BID regulation by p53 contributes to chemosensitivity

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Dissecting p53 tumor suppressor functions in vivo

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Mechanisms of p53-dependent apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

A phase I study of adenovirus-mediated wild-type p53 gene transfer in patients with advanced non-small cell lung cancer

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p53 triggers apoptosis in oncogene-expressing fibroblasts by the induction of Noxa and mitochondrial Bax translocation

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Cell nucleus and DNA fragmentation are not required for apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

The RB and p53 pathways in cancer

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Cancer modeling in the modern era: progress and challenges

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Surfing the p53 network

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Structure-based rescue of common tumor-derived p53 mutants

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

p21 is a universal inhibitor of cyclin kinases

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

PUMA induces the rapid apoptosis of colorectal cancer cells

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Role of BAX in the apoptotic response to anticancer agents

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

Definition of the p53 functional domains necessary for inducing apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900272-1

7 January 2021

10.1016/S1535-6108(03)00272-1

Identifiers

DOI

1 reference

5 December 2017

1 reference

PubMed ID

14667504