Dangerous habits of a security guard: the two faces of p53 as a drug target (Q36871609)

16 August 2017

1 reference

title

Dangerous habits of a security guard: the two faces of p53 as a drug target (English)

1 reference

16 August 2017

Andrei V Gudkov

1

1 reference

PubMed ID

17613549

16 August 2017

Elena A Komarova

series ordinal

2

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16 August 2017

1 April 2007

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16 August 2017

Human Molecular Genetics

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16 August 2017

16 Spec No 1

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16 August 2017

R67-72

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

16 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Tumor spectrum analysis in p53-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Tumor surveillance via the ARF-p53 pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The MDM2 gene amplification database

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Twenty years of p53 research: structural and functional aspects of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The p53-Mdm2 module and the ubiquitin system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The ARF tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Regulation of p53 downstream genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Regulation of the p53 transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Dynamics of the p53-Mdm2 feedback loop in individual cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The role of p53 in determining sensitivity to radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The antioxidant function of the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Small peptides activate the latent sequence-specific DNA binding function of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The role of the E6-p53 interaction in the molecular pathogenesis of HPV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

p53 Activation by small molecules: application in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

NF-kappaB in cancer: a marked target

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

p53 Involvement in the control of murine hair follicle regression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Could p53 be a target for therapeutic suppression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Prospective therapeutic applications of p53 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Apoptosis in ischemic renal injury: roles of GTP depletion and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDM052

21 January 2018

Identifiers

DOI

10.1093/HMG/DDM052

1 reference

release_njs2oafzenbprjsegrmxyoonz4

16 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/njs2oafzenbprjsegrmxyoonz4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

17613549

1 reference

PubMed ID

17613549