The p53-Mdm2 module and the ubiquitin system. (Q35036580)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

title

The p53-Mdm2 module and the ubiquitin system (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

author name string

Moshe Oren

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

publication date

1 February 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

Seminars in Cancer Biology

16 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

page(s)

49-58

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12507556%20AND%20SRC:MED&resulttype=core&format=json

publication type of scholarly work

16 December 2019

review article

1 reference

The p53 and Mdm2 families in cancer.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Multiple roles of the tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The ins and outs of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Regulation of p53 function

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

1 reference

7 January 2021

Virus-mediated killing of cells that lack p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

A model for tumor suppression using H-1 parvovirus

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

MDM2: life without p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The MDM2 oncoprotein binds specifically to RNA through its RING finger domain

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Identification of a cryptic nucleolar-localization signal in MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The loss of mdm2 induces p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Regulation of Mdm2-Directed Degradation by the C Terminus of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

C-terminal ubiquitination of p53 contributes to nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Recognition of the polyubiquitin proteolytic signal

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Ubiquitin-mediated proteolysis: biological regulation via destruction

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Novel phosphorylation sites of human tumour suppressor protein p53 at Ser20 and Thr18 that disrupt the binding of mdm2 (mouse double minute 2) protein are modified in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Regulation of p53 function and stability by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The mdm-2 gene is induced in response to UV light in a p53-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Stress signals utilize multiple pathways to stabilize p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

p53 Activation by nitric oxide involves down-regulation of Mdm2.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

1 reference

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Polyoma virus disrupts ARF signaling to p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

MDM2 and MDMX can interact differently with ARF and members of the p53 family

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

p53 accumulation, defective cell proliferation, and early embryonic lethality in mice lacking tsg101.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

c-Abl neutralizes the inhibitory effect of Mdm2 on p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The contribution of the acidic domain of MDM2 to p53 and MDM2 stability

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Mdm2 mutant defective in binding p300 promotes ubiquitination but not degradation of p53: evidence for the role of p300 in integrating ubiquitination and proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Physical association of ubiquitin ligases and the 26S proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Phosphorylation of murine double minute clone 2 (MDM2) protein at serine-267 by protein kinase CK2 in vitro and in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The MDM2 RING-finger domain is required to promote p53 nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

MDM2-dependent ubiquitination of nuclear and cytoplasmic P53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Nuclear degradation of p53 occurs during down‐regulation of the p53 response after DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Proteolysis by calpains: a possible contribution to degradation of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

On the involvement of calpains in the degradation of the tumor suppressor protein p53

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

The death substrate Gas2 binds m-calpain and increases susceptibility to p53-dependent apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

MEKK1/JNK signaling stabilizes and activates p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021

JNK targets p53 ubiquitination and degradation in nonstressed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1044-579X%2802%2900099-8

7 January 2021