Utilizing RNA interference to enhance cancer drug discovery (Q36864047)

16 August 2017

title

Utilizing RNA interference to enhance cancer drug discovery (English)

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16 August 2017

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Elizabeth Iorns

1

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Christopher J Lord

object named as

Christopher J Lord

series ordinal

2

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Alan Ashworth

series ordinal

4

object named as

Alan Ashworth

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16 August 2017

Nicholas Turner

3

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16 August 2017

publication date

1 July 2007

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Nature Reviews Drug Discovery

16 August 2017

language of work or name

English

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published in

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16 August 2017

volume

6

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16 August 2017

issue

7

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16 August 2017

page(s)

556-568

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publication type of scholarly work

16 August 2017

review article

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New approaches to molecular cancer therapeutics

cites work

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Why is cancer drug discovery so difficult?

31 March 2020

1 reference

Protein kinase C epsilon is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy

31 March 2020

1 reference

Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

31 March 2020

1 reference

Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells

31 March 2020

1 reference

Introduction of a Chimeric Chalcone Synthase Gene into Petunia Results in Reversible Co-Suppression of Homologous Genes in trans

31 March 2020

1 reference

Inhibition of viruses by RNA interference

31 March 2020

1 reference

On the origin and functions of RNA-mediated silencing: from protists to man

31 March 2020

1 reference

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

31 March 2020

1 reference

A system for stable expression of short interfering RNAs in mammalian cells

31 March 2020

1 reference

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

31 March 2020

1 reference

Aurora-B/AIM-1 kinase activity is involved in Ras-mediated cell transformation.

31 March 2020

1 reference

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

31 March 2020

1 reference

A resource for large-scale RNA-interference-based screens in mammals.

31 March 2020

1 reference

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

31 March 2020

1 reference

Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells

31 March 2020

1 reference

An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division

31 March 2020

1 reference

Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies

31 March 2020

1 reference

Different susceptibility of osteosarcoma cell lines and primary cells to treatment with oncolytic adenovirus and doxorubicin or cisplatin

31 March 2020

1 reference

A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

31 March 2020

1 reference

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance.

31 March 2020

1 reference

RNA interference microarrays: high-throughput loss-of-function genetics in mammalian cells

31 March 2020

1 reference

Microarrays of lentiviruses for gene function screens in immortalized and primary cells

31 March 2020

1 reference

An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors

31 March 2020

1 reference

A loss-of-function RNA interference screen for molecular targets in cancer

31 March 2020

1 reference

A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase

31 March 2020

1 reference

The concept of synthetic lethality in the context of anticancer therapy

31 March 2020

1 reference

Cancer. Addiction to oncogenes--the Achilles heal of cancer

31 March 2020

1 reference

The development of imatinib as a therapeutic agent for chronic myeloid leukemia

31 March 2020

1 reference

Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

31 March 2020

1 reference

Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.

31 March 2020

1 reference

A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3beta/FBW7 loss of function

31 March 2020

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

A genetic screen for candidate tumor suppressors identifies REST

31 March 2020

1 reference

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

31 March 2020

1 reference

Integrating Genetic Approaches into the Discovery of Anticancer Drugs

31 March 2020

1 reference

Use of isogenic human cancer cells for high-throughput screening and drug discovery

31 March 2020

1 reference

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

31 March 2020

1 reference

RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors.

31 March 2020

1 reference

Probing the human kinome for kinases involved in pancreatic cancer cell survival and gemcitabine resistance

31 March 2020

1 reference

Synthetic lethal screen identification of chemosensitizer loci in cancer cells

31 March 2020

1 reference

Mediators of vascular remodelling co-opted for sequential steps in lung metastasis.

31 March 2020

1 reference

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes

31 March 2020

1 reference

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

31 March 2020

1 reference

The knockout mouse project

31 March 2020

1 reference

Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype

31 March 2020

1 reference

Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice

31 March 2020

1 reference

In vivo RNA interference demonstrates a role for Nramp1 in modifying susceptibility to type 1 diabetes.

31 March 2020

1 reference

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

1 reference

Restoration of p53 function leads to tumour regression in vivo

31 March 2020

1 reference

siRNAs can function as miRNAs

31 March 2020

1 reference

Minimizing the risk of reporting false positives in large-scale RNAi screens

31 March 2020

1 reference

Chemical genetics: where genetics and pharmacology meet

31 March 2020

1 reference

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

31 March 2020

1 reference

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo

31 March 2020

1 reference

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets

31 March 2020

1 reference

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

31 March 2020

1 reference

A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling

31 March 2020

1 reference

Genome-wide RNAi analysis of growth and viability in Drosophila cells

31 March 2020

1 reference

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

31 March 2020

1 reference

High-throughput screening by RNA interference: control of two distinct types of variance

31 March 2020

1 reference

3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

31 March 2020

1 reference

Targeted mRNA degradation by double-stranded RNA in vitro

31 March 2020

1 reference

Mechanisms of gene silencing by double-stranded RNA

31 March 2020

1 reference

RNA interference: mechanisms of action and therapeutic consideration

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD2355

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Dimensions Publication ID

16 August 2017

1047676324

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