Mechanisms of gene silencing by double-stranded RNA (Q28282560)

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Europe PubMed Central

title

Mechanisms of gene silencing by double-stranded RNA (English)

0 references

0 references

2

Thomas Tuschl

0 references

author name string

Gunter Meister

series ordinal

1

0 references

language of work or name

English

0 references

publication date

16 September 2004

0 references

published in

Nature

0 references

volume

431

0 references

page(s)

343-9

0 references

issue

7006

0 references

cites work

1 reference

The genetics of RNA silencing

20 April 2017

1 reference

MicroRNA maturation: stepwise processing and subcellular localization

20 April 2017

1 reference

The nuclear RNase III Drosha initiates microRNA processing

20 April 2017

1 reference

Human let-7 stem-loop precursors harbor features of RNase III cleavage products

20 April 2017

1 reference

Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

20 April 2017

1 reference

Nuclear export of microRNA precursors

20 April 2017

1 reference

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

20 April 2017

1 reference

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

20 April 2017

1 reference

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

20 April 2017

1 reference

Genetic and functional diversification of small RNA pathways in plants

20 April 2017

1 reference

Role for a bidentate ribonuclease in the initiation step of RNA interference

20 April 2017

1 reference

RNA interference is mediated by 21- and 22-nucleotide RNAs

20 April 2017

1 reference

Ribonuclease activity and RNA binding of recombinant human Dicer

20 April 2017

1 reference

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

20 April 2017

1 reference

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

20 April 2017

1 reference

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

20 April 2017

1 reference

A microRNA in a multiple-turnover RNAi enzyme complex

20 April 2017

1 reference

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

20 April 2017

1 reference

Functional siRNAs and miRNAs Exhibit Strand Bias

20 April 2017

1 reference

Asymmetry in the assembly of the RNAi enzyme complex

20 April 2017

1 reference

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

20 April 2017

1 reference

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

20 April 2017

1 reference

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

20 April 2017

1 reference

Identification of eight members of the Argonaute family in the human genome

20 April 2017

1 reference

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

20 April 2017

1 reference

Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs

20 April 2017

1 reference

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

20 April 2017

1 reference

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

20 April 2017

1 reference

Identification of many microRNAs that copurify with polyribosomes in mammalian neurons

20 April 2017

1 reference

RNA silencing as a plant immune system against viruses

20 April 2017

1 reference

Size selective recognition of siRNA by an RNA silencing suppressor

20 April 2017

1 reference

Recognition of small interfering RNA by a viral suppressor of RNA silencing

20 April 2017

1 reference

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

20 April 2017

1 reference

Identification of virus-encoded microRNAs

20 April 2017

1 reference

RNAi-mediated targeting of heterochromatin by the RITS complex

20 April 2017

1 reference

SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis

20 April 2017

1 reference

MicroRNAs: genomics, biogenesis, mechanism, and function

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

ATP requirements and small interfering RNA structure in the RNA interference pathway

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Argonaute2, a link between genetic and biochemical analyses of RNAi

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

siRNAs can function as miRNAs

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Induction and suppression of RNA silencing by an animal virus

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

RNA interference in protozoan parasites

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Gene silencing as an adaptive defence against viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Arabidopsis HEN1: a genetic link between endogenous miRNA controlling development and siRNA controlling transgene silencing and virus resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

The nuclear dsRNA binding protein HYL1 is required for microRNA accumulation and plant development, but not posttranscriptional transgene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

RISC is a 5' phosphomonoester-producing RNA endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

RISC assembly defects in the Drosophila RNAi mutant armitage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

The Arabidopsis heterochronic gene ZIPPY is an ARGONAUTE family member.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

A micrococcal nuclease homologue in RNAi effector complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

The RNA-induced silencing complex is a Mg2+-dependent endonuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

A model for RNA-mediated gene silencing in higher plants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

On the role of RNA amplification in dsRNA-triggered gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

RNAi: mammalian oocytes do it without RNA-dependent RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Role of short RNAs in gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Viral suppressors of RNA silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

The role of RNA editing by ADARs in RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Activation of MYC in a masked t(8;17) translocation results in an aggressive B-cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

AGO1 defines a novel locus of Arabidopsis controlling leaf development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

A link between RNA interference and nonsense-mediated decay in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

RNA silencing genes control de novo DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Spatially restricted microRNA directs leaf polarity through ARGONAUTE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

Crystal structure of Argonaute and its implications for RISC slicer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

inferred from DOI database lookup

7 January 2021

based on heuristic

RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

inferred from DOI database lookup

7 January 2021

based on heuristic

A gene encoding an RNase D exonuclease-like protein is required for post-transcriptional silencing in Arabidopsis

1 reference

https://api.crossref.org/works/10.1038%2FNATURE02873

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE02873

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1767755

1049891178

0 references

1767755

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference