Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs (Q24299641)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0090624

mRNA destabilization-mediated gene silencing by siRNA

2 references

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0090625

Argonaute RISC component 4

1 reference

Argonaute RISC component 1

1 reference

Argonaute RISC catalytic component 3

1 reference

Argonaute RISC catalytic component 2

1 reference

author

Thomas Tuschl

6

0 references

Markus Landthaler

2

0 references

author name string

Gunter Meister

1

0 references

Agnieszka Patkaniowska

3

0 references

Yair Dorsett

4

0 references

Grace Teng

The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation

5

0 references

publication date

23 July 2004

0 references

language of work or name

0 references

0 references

15

0 references

issue

2

0 references

page(s)

185-97

0 references

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNA oligonucleotide synthesis via 5'-silyl-2'-orthoester chemistry

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Post-transcriptional gene silencing in plants by RNA.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Induction of nuclear lamins A/C in macrophages in in vitro cultures of rat bone marrow precursor cells and human blood monocytes, and in macrophages elicited in vivo by thioglycollate stimulation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Single processing center models for human Dicer and bacterial RNase III

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

microRNAs: runts of the genome assert themselves

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Structure and mechanism of RNA ligase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Isolation and functional characterization of the TRAP/mediator complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Single-stranded antisense siRNAs guide target RNA cleavage in RNAi

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Asymmetry in the assembly of the RNAi enzyme complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

MicroRNAs: genomics, biogenesis, mechanism, and function

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RISC assembly defects in the Drosophila RNAi mutant armitage.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Identification of eight members of the Argonaute family in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

A branched pathway for transgene-induced RNA silencing in plants

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Identification of tissue-specific microRNAs from mouse

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

SMN-mediated assembly of RNPs: a complex story

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNAi: an ever-growing puzzle

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

DICER-LIKE1: blind men and elephants in Arabidopsis development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The small RNA profile during Drosophila melanogaster development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Role for a bidentate ribonuclease in the initiation step of RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Gene silencing as an adaptive defence against viruses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

1 reference

7 January 2021

An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The nuclear RNase III Drosha initiates microRNA processing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Control of leaf morphogenesis by microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Structure and conserved RNA binding of the PAZ domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Spatially restricted microRNA directs leaf polarity through ARGONAUTE1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Rational siRNA design for RNA interference

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The microRNA-producing enzyme Dicer1 is essential for zebrafish development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Dicer is essential for mouse development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

siRNAs: applications in functional genomics and potential as therapeutics

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Killing the messenger: short RNAs that silence gene expression

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNase III enzymes and the initiation of gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Kinetic analysis of the RNAi enzyme complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

ARGONAUTE1 is required for efficient RNA interference in Drosophila embryos

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Suppression of gene silencing: a general strategy used by diverse DNA and RNA viruses of plants

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

AGO1 defines a novel locus of Arabidopsis controlling leaf development.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Two classes of short interfering RNA in RNA silencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

MicroRNA maturation: stepwise processing and subcellular localization

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Ribonuclease activity and RNA binding of recombinant human Dicer

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

1 reference

7 January 2021

A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

A biochemical framework for RNA silencing in plants

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The action of ARGONAUTE1 in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Targeted mRNA degradation by double-stranded RNA in vitro

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNA interference is mediated by 21- and 22-nucleotide RNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Short RNAs can identify new candidate transposable element families in Arabidopsis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genes

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNA interference in protozoan parasites

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Argonaute2, a link between genetic and biochemical analyses of RNAi

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Identification of Novel Genes Coding for Small Expressed RNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Induction and suppression of RNA silencing by an animal virus

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNA silencing: the genome's immune system

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

A microRNA in a multiple-turnover RNAi enzyme complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Role of microRNAs in plant and animal development

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Heterochromatin and epigenetic control of gene expression

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNAi-mediated targeting of heterochromatin by the RITS complex

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

RNA silencing genes control de novo DNA methylation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Identification of virus-encoded microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

MicroRNA-directed cleavage of HOXB8 mRNA

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Transgene and transposon silencing in Chlamydomonas reinhardtii by a DEAH-box RNA helicase

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Redundancy of the two dicer genes in transgene-induced posttranscriptional gene silencing in Neurospora crassa

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

The genetics of RNA silencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Mili, a mammalian member of piwi family gene, is essential for spermatogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

1 reference

7 January 2021

Numerous microRNPs in neuronal cells containing novel microRNAs

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Sequence-specific inhibition of small RNA function

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Genetic and functional diversification of small RNA pathways in plants

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021

Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2004.07.007

7 January 2021