Mitochondriotoxic compounds for cancer therapy (Q36558020)

14 August 2017

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title

Mitochondriotoxic compounds for cancer therapy (English)

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14 August 2017

Fantin VR

1

1 reference

PubMed ID

16892091

14 August 2017

Leder P

series ordinal

2

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PubMed ID

16892091

14 August 2017

language of work or name

English

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publication date

1 August 2006

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14 August 2017

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14 August 2017

25

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14 August 2017

4787-4797

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14 August 2017

34

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209599

14 August 2017

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cites work

Paclitaxel targets mitochondria upstream of caspase activation in intact human neuroblastoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Relation of cell proliferation to expression of peripheral benzodiazepine receptors in human breast cancer cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondria and cell death. Mechanistic aspects and methodological issues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Particle assembly incorporating a VP22-BH3 fusion protein, facilitating intracellular delivery, regulated release, and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Anti-microbial peptides: from invertebrates to vertebrates.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial Membrane Potential in Living Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

ANT2 isoform required for cancer cell glycolysis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

1 reference

7 January 2021

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Oncogenic alterations of metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Targeted proapoptotic LHRH-BH3 peptide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

A fourth ADP/ATP carrier isoform in man: identification, bacterial expression, functional characterization and tissue distribution

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Anti-cancer activity of targeted pro-apoptotic peptides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mechanisms for the modulation of membrane bilayer properties by amphipathic helical peptides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Genetic dissection of the permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Targeting programmed cell death pathways with experimental therapeutics: opportunities in high-risk neuroblastoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondria and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Targeted delivery of a peripheral benzodiazepine receptor ligand-gemcitabine conjugate to brain tumors in a xenograft model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Superoxide dismutase as a target for the selective killing of cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Radioresistance in carcinoma of the breast

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

De novo antimicrobial peptides with low mammalian cell toxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Intrinsic and extrinsic uncoupling of oxidative phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The concept of synthetic lethality in the context of anticancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Effect of the lipophilic/hydrophilic character of cationic triarylmethane dyes on their selective phototoxicity toward tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Alterations of mitochondrial DNA in common diseases and disease states: aging, neurodegeneration, heart failure, diabetes, and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Reactive oxygen species and mitochondrial diseases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Dysregulation of apoptosis genes in hematopoietic malignancies.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Reversal of obesity by targeted ablation of adipose tissue

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The anti-apoptotic genes Bcl-X(L) and Bcl-2 are over-expressed and contribute to chemoresistance of non-proliferating leukaemic CD34+ cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Introduction: mitochondrial control of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The mitochondrial death/life regulator in apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Arsenic trioxide, a novel mitochondriotoxic anticancer agent?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial control of cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Bcl-2-family proteins and the role of mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Photophysical, photochemical, and tumor-selectivity properties of bromine derivatives of rhodamine-123.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Pore protein and the hexokinase-binding protein from the outer membrane of rat liver mitochondria are identical

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Hypersensitization of tumor cells to glycolytic inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Translocation of loops regulates transport activity of mitochondrial ADP/ATP carrier deduced from formation of a specific intermolecular disulfide bridge catalyzed by copper-o-phenanthroline.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Importance of loops of mitochondrial ADP/ATP carrier for its transport activity deduced from reactivities of its cysteine residues with the sulfhydryl reagent eosin-5-maleimide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

To use MIBI or not to use MIBI? That is the question when assessing tumour cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

INTRAMITOCHONDRIAL FIBERS WITH DNA CHARACTERISTICS. I. FIXATION AND ELECTRON STAINING REACTIONS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondria: releasing power for life and unleashing the machineries of death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial superoxide dismutase: a promising target for new anticancer therapies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Hexokinase II: the integration of energy metabolism and control of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial bound type II hexokinase: a key player in the growth and survival of many cancers and an ideal prospect for therapeutic intervention

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

ROS stress in cancer cells and therapeutic implications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Phase I trial of the selective mitochondrial toxin MKT 077 in chemo-resistant solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondria, the killer organelles and their weapons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Dysregulation of apoptosis in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

DNA methylation is required for silencing of ant4, an adenine nucleotide translocase selectively expressed in mouse embryonic stem cells and germ cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial DNA damage by anticancer agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial DNA determines the cellular response to cancer therapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Delivery of bioactive molecules to mitochondria in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Unusual retention of rhodamine 123 by mitochondria in muscle and carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Intracellular distribution of a platinum-rhodamine 123 complex in cis-platinum sensitive and resistant human squamous carcinoma cell lines.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

A predictive model for the selective accumulation of chemicals in tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Increased expression of peripheral benzodiazepine receptors and diazepam binding inhibitor in human tumors sited in the liver

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

PK11195, a peripheral benzodiazepine receptor (pBR) ligand, broadly blocks drug efflux to chemosensitize leukemia and myeloma cells by a pBR-independent, direct transporter-modulating mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial pharmaceutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial delivery of mastoparan with transferrin liposomes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Mitochondrial permeability transition in apoptosis and necrosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209599

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209599

1 reference

14 August 2017

1 reference

PubMed ID

16892091