Nucleophosmin and cancer (Q36516405)

14 August 2017

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title

Nucleophosmin and cancer (English)

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14 August 2017

4

Pier Paolo Pandolfi

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Brunangelo Falini

series ordinal

3

object named as

Brunangelo Falini

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14 August 2017

1

Silvia Grisendi

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14 August 2017

Cristina Mecucci

2

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PubMed ID

16794633

14 August 2017

language of work or name

English

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publication date

1 July 2006

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14 August 2017

Nature Reviews Cancer

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14 August 2017

6

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14 August 2017

7

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14 August 2017

493-505

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https://scigraph.springernature.com/pub.10.1038/nrc1885

14 August 2017

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cites work

A constitutive nucleolar protein identified as a member of the nucleoplasmin family.

1 reference

DNA cloning and amino acid sequence determination of a major constituent protein of mammalian nucleoli. Correspondence of the nucleoplasmin-related protein NO38 to mammalian protein B23.

31 March 2020

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Characterization of the cDNA encoding human nucleophosmin and studies of its role in normal and abnormal growth

31 March 2020

1 reference

Role of nucleophosmin in embryonic development and tumorigenesis

31 March 2020

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Nucleophosmin is required for DNA integrity and p19Arf protein stability

31 March 2020

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

31 March 2020

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Major nucleolar proteins shuttle between nucleus and cytoplasm

31 March 2020

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Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix

31 March 2020

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Mapping the functional domains of nucleolar protein B23

31 March 2020

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Nucleolar protein B23 has molecular chaperone activities

31 March 2020

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Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone

31 March 2020

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Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription

31 March 2020

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Sedimentation analyses of the salt- and divalent metal ion-induced oligomerization of nucleolar protein B23

31 March 2020

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The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus

31 March 2020

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The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype

31 March 2020

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Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

31 March 2020

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Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD

31 March 2020

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EXPRESSION OF NUCLEOPHOSMIN/B23 IN NORMAL AND NEOPLASTIC COLORECTAL MUCOSA

31 March 2020

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Induction of immune responses to ovarian tumor antigens by multiparity

31 March 2020

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Monoclonal antibody to prostate cancer nuclear matrix protein (PRO:4-216) recognizes nucleophosmin/B23

31 March 2020

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Association of nucleophosmin/B23 mRNA expression with clinical outcome in patients with bladder carcinoma.

31 March 2020

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Two-dimensional gel electrophoresis analyses identify nucleophosmin as an estrogen regulated protein associated with acquired estrogen-independence in human breast cancer cells

31 March 2020

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

31 March 2020

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Frequent loss of heterozygosity on chromosome 5 in non-small cell lung carcinoma

31 March 2020

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Loss of the NPM1 gene in myeloid disorders with chromosome 5 rearrangements.

31 March 2020

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Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

31 March 2020

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In vivo and in vitro phosphorylation studies of numatrin, a cell cycle regulated nuclear protein, in insulin-stimulated NIH 3T3 HIR cells

31 March 2020

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Gene expression in proliferating human erythroid cells

31 March 2020

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A major nucleolar protein B23 as a marker of proliferation activity of human peripheral lymphocytes

31 March 2020

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Characterization of nucleophosmin (B23) as a Myc target by scanning chromatin immunoprecipitation

31 March 2020

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N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

31 March 2020

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Nucleolar protein B23.1 binds to retinoblastoma protein and synergistically stimulates DNA polymerase alpha activity

31 March 2020

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Down-regulation of nucleophosmin/B23 during retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.

31 March 2020

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Decrease in nucleophosmin/B23 mRNA and telomerase activity during indomethacin-induced apoptosis of gastric KATO-III cancer cells

31 March 2020

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c-Myc-mediated expression of nucleophosmin/B23 decreases during retinoic acid-induced differentiation of human leukemia HL-60 cells.

31 March 2020

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Down-regulation of nucleophosmin/B23 mRNA delays the entry of cells into mitosis

31 March 2020

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Berberine-induced apoptosis of human leukemia HL-60 cells is associated with down-regulation of nucleophosmin/B23 and telomerase activity

31 March 2020

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Over-expression of nucleophosmin/B23 decreases the susceptibility of human leukemia HL-60 cells to retinoic acid-induced differentiation and apoptosis

31 March 2020

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ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

31 March 2020

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Interaction of nucleolar phosphoprotein B23 with nucleic acids

31 March 2020

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Comparison of proteins of ribosomal subunits and nucleolar preribosomal particles from Novikoff hepatoma ascites cells by two-dimensional polyacrylamide gel electrophoresis

31 March 2020

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Preribosomal ribonucleoprotein particles are a major component of a nucleolar matrix fraction

31 March 2020

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The ribonuclease activity of nucleolar protein B23.

31 March 2020

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Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

31 March 2020

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Does the ribosome translate cancer?

31 March 2020

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Translocations involving c-myc and c-myc function

31 March 2020

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Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

31 March 2020

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Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

31 March 2020

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Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation

31 March 2020

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Nucleophosmin/B23, a multifunctional protein that can regulate apoptosis

31 March 2020

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Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

31 March 2020

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Resistance to UV-induced cell-killing in nucleophosmin/B23 over-expressed NIH 3T3 fibroblasts: enhancement of DNA repair and up-regulation of PCNA in association with nucleophosmin/B23 over-expression

31 March 2020

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IRF-1 as a negative regulator of cell proliferation

31 March 2020

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Hypoxia-induced nucleophosmin protects cell death through inhibition of p53.

31 March 2020

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Host defense, viruses and apoptosis

31 March 2020

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PKR, apoptosis and cancer

31 March 2020

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Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR

31 March 2020

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Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells

31 March 2020

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Translocation of nucleolar phosphoprotein B23 (37 kDa/pI 5.1) induced by selective inhibitors of ribosome synthesis

31 March 2020

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Phosphoprotein B23 translocation and modulation of actinomycin D and doxorubicin cytotoxicity by dipyridamole in HeLa cells

31 March 2020

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Characterization and cellular localization of nucleophosmin/B23 in HeLa cells treated with selected cytotoxic agents (studies of B23-translocation mechanism)

31 March 2020

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Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiation

31 March 2020

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Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

31 March 2020

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Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element

31 March 2020

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The cytotoxicity of human immunodeficiency virus type 1 Rev: implications for its interaction with the nucleolar protein B23

31 March 2020

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The nucleolar phosphoprotein B23 interacts with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication.

31 March 2020

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Nucleophosmin/B23-binding peptide inhibits tumor growth and up-regulates transcriptional activity of p53.

31 March 2020

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Nucleolar Arf sequesters Mdm2 and activates p53

31 March 2020

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

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Defining the molecular basis of Arf and Hdm2 interactions

31 March 2020

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N-terminal polyubiquitination and degradation of the Arf tumor suppressor

31 March 2020

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The INK4a/ARF network in tumour suppression

31 March 2020

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Tumor surveillance via the ARF-p53 pathway.

31 March 2020

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Nucleophosmin (B23) targets ARF to nucleoli and inhibits its function

31 March 2020

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Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

31 March 2020

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

31 March 2020

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Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein

31 March 2020

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Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

31 March 2020

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p53, the cellular gatekeeper for growth and division

31 March 2020

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Regulation of the p53 tumor suppressor protein

31 March 2020

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Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

31 March 2020

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Cancer: guarding the guardian?

31 March 2020

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Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

31 March 2020

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Nucleophosmin regulates the stability and transcriptional activity of p53

31 March 2020

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

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GADD45 induction of a G2/M cell cycle checkpoint

31 March 2020

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Genomic instability in Gadd45a-deficient mice

31 March 2020

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B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest

31 March 2020

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A proteomics approach for the identification of nucleophosmin and heterogeneous nuclear ribonucleoprotein C1/C2 as chromatin-binding proteins in response to DNA double-strand breaks

31 March 2020

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Mitotic kinases as regulators of cell division and its checkpoints

31 March 2020

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Different kinases phosphorylate nucleophosmin/B23 at different sites during G(2) and M phases of the cell cycle

31 March 2020

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Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

31 March 2020

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The major phosphorylation site of nucleophosmin (B23) is phosphorylated by a nuclear kinase II

31 March 2020

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Identification of major nucleolar proteins as candidate mitotic substrates of cdc2 kinase

31 March 2020

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31 March 2020

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The chromosome periphery during mitosis

31 March 2020

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The dynamics of postmitotic reassembly of the nucleolus

31 March 2020

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NuMA, a nuclear protein involved in mitosis and nuclear reformation.

31 March 2020

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Nek2A kinase regulates the localization of numatrin to centrosome in mitosis

31 March 2020

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B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.

31 March 2020

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31 March 2020

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Requirement of Cdk2-cyclin E activity for repeated centrosome reproduction in Xenopus egg extracts

31 March 2020

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Substrate specificity and cell cycle regulation of the Nek2 protein kinase, a potential human homolog of the mitotic regulator NIMA of Aspergillus nidulans.

31 March 2020

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The Nek2 protein kinase: a novel regulator of centrosome structure

31 March 2020

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Never say never. The NIMA-related protein kinases in mitotic control

31 March 2020

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Proteomic characterization of the human centrosome by protein correlation profiling

31 March 2020

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Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication.

31 March 2020

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The role of nucleophosmin in centrosome duplication

31 March 2020

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The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

31 March 2020

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Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

31 March 2020

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Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase

31 March 2020

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

31 March 2020

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Inactivation of E2F3 results in centrosome amplification

31 March 2020

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Running on Ran: nuclear transport and the mitotic spindle.

31 March 2020

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Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles

31 March 2020

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Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

31 March 2020

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Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

31 March 2020

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Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity

31 March 2020

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Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1

31 March 2020

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Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization

31 March 2020

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Translocations involving anaplastic lymphoma kinase (ALK).

31 March 2020

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Anaplastic large cell lymphoma: pathological, molecular and clinical features.

31 March 2020

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Variations on a theme: the alternate translocations in APL.

31 March 2020

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Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1885

1 reference

14 August 2017

1 reference

PubMed ID

16794633