Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. (Q43594592)

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7 November 2019

title

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus (English)

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7 November 2019

1

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7 November 2019

author name string

P A Clark

series ordinal

2

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7 November 2019

J Rowe

series ordinal

3

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7 November 2019

G Peters

series ordinal

4

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7 November 2019

language of work or name

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1 May 2001

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7 November 2019

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volume

3

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issue

5

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7 November 2019

page(s)

445-452

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Tumor surveillance via the ARF-p53 pathway.

7 November 2019

cites work

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7 January 2021

CDK inhibitors: positive and negative regulators of G1-phase progression

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7 January 2021

The INK4A/ARF locus and its two gene products

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7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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7 January 2021

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

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7 January 2021

Distinct roles for E2F proteins in cell growth control and apoptosis

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7 January 2021

p14ARF links the tumour suppressors RB and p53.

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7 January 2021

Contribution of two independent MDM2-binding domains in p14(ARF) to p53 stabilization

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7 January 2021

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

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7 January 2021

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

Immunolocalization of human p14(ARF) to the granular component of the interphase nucleolus

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7 January 2021

Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization.

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7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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7 January 2021

p53 functions as a cell cycle control protein in osteosarcomas

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7 January 2021

Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor

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7 January 2021

p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts.

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7 January 2021

Methods used to study structure and function of the nucleolus

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7 January 2021

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

1 reference

7 January 2021

Aggresomes: a cellular response to misfolded proteins

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7 January 2021

Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

1 reference

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

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7 January 2021

Identification of a cryptic nucleolar-localization signal in MDM2

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7 January 2021

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

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7 January 2021

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

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7 January 2021

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Identifiers

DOI

10.1038/35074506

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11331871%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

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