Fusion tyrosine kinases: a result and cause of genomic instability (Q36512142)

14 August 2017

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title

Fusion tyrosine kinases: a result and cause of genomic instability (English)

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14 August 2017

Penserga ET

1

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14 August 2017

Skorski T

series ordinal

2

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14 August 2017

language of work or name

English

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publication date

19 June 2006

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14 August 2017

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14 August 2017

26

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14 August 2017

1

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14 August 2017

11-20

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209756

14 August 2017

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cites work

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7 January 2021

Mapping oxidative DNA damage and mechanisms of repair

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7 January 2021

The karyotype of blastic crisis

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7 January 2021

CD30+ lymphoproliferative disorder: primary cutaneous anaplastic large cell lymphoma followed by lymphomatoid papulosis

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7 January 2021

Causes of oncogenic chromosomal translocation

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7 January 2021

Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The cellular response to general and programmed DNA double strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Oxidative Decay of DNA

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Oncogenic kinase signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

High frequency of point mutations clustered within the adenosine triphosphate-binding region of BCR/ABL in patients with chronic myeloid leukemia or Ph-positive acute lymphoblastic leukemia who develop imatinib (STI571) resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The biology of CML blast crisis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Structural alterations of the BCR and ABL genes in Ph1 positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Ribozyme minigene-mediated RAD51 down-regulation increases radiosensitivity of human prostate cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Tyrosine kinase fusion genes in chronic myeloproliferative diseases.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Chronic myeloproliferative disorders: a tyrosine kinase tale.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

BCR-ABL down-regulates the DNA repair protein DNA-PKcs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Double-strand breaks and translocations in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Chromosomal translocation mechanisms at intronic alu elements in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Molecular genetic advances in chronic myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Fusion of the BCR and the fibroblast growth factor receptor-1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: the first fusion gene involving BCR but not ABL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Role of alpha1 acid glycoprotein in the in vivo resistance of human BCR-ABL(+) leukemic cells to the abl inhibitor STI571

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Treatment of Chronic Myeloid Leukemia Cells with Imatinib (STI571) Impairs p53 Accumulation in Response to DNA Damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Expression of the oncogenic NPM-ALK chimeric protein in human lymphoid T-cells inhibits drug-induced, but not Fas-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Critical role of STAT5 activation in transformation mediated by ZNF198-FGFR1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Fusion oncogenic tyrosine kinases alter DNA damage and repair after genotoxic treatment: role in drug resistance?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Radical causes of cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Protein tyrosine kinases and cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Chronic myelogenous leukemia occurring in two brothers diagnosed 26 years apart

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Mechanism and regulation of human non-homologous DNA end-joining

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Familial chronic myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Apoptosis and cancer chemotherapy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The base substitution fidelity of DNA polymerase beta-dependent single nucleotide base excision repair.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

1 reference

7 January 2021

The Tel-Abl (ETV6-Abl) tyrosine kinase, product of complex (9;12) translocations in human leukemia, induces distinct myeloproliferative disease in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Mechanisms and implications of imatinib resistance mutations in BCR-ABL.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Chromosomal abnormalities in nodal and extranodal CD30+ anaplastic large cell lymphomas: infrequent detection of the t(2;5) in extranodal lymphomas.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Characterization of the translocation breakpoint sequences in Philadelphia-positive acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Genomic integrity and the repair of double-strand DNA breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Cancer incidence in atomic bomb survivors. Part III. Leukemia, lymphoma and multiple myeloma, 1950-1987.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Chromosomal translocations in human cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Characterization of prostate cancer missed by sextant biopsy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Nucleotide excision repair in chromatin: the shape of things to come

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Frequent chromosomal translocations induced by DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The protein tyrosine kinase family of the human genome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Non-traditional Alu evolution and primate genomic diversity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

One short well conserved region of Alu-sequences is involved in human gene rearrangements and has homology with prokaryotic chi.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Disabling Abl-perspectives on Abl kinase regulation and cancer therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Cellular and molecular dissection of reperfusion injury: ROS within and without

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Consistent loss of heterozygosity at 14Q32 in lymphoid blast crisis of chronic myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Involvement of DNA polymerase beta in DNA replication and mutagenic consequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Overriding imatinib resistance with a novel ABL kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Chronic myelogenous leukemia: mechanisms underlying disease progression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Molecular evolution of chronic myeloid leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Oncogenic tyrosine kinases and the DNA-damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The interacting pathways for prevention and repair of oxidative DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

BCR/ABL recruits p53 tumor suppressor protein to induce drug resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Common chromatin structures at breakpoint cluster regions may lead to chromosomal translocations found in chronic and acute leukemias

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Identification of translocational breakpoints within the intron region before the last coding exon (exon 12) of the EVI1 gene in two cases of CML-BC with inv(3)(q21q26).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Homologous recombinational repair of DNA ensures mammalian chromosome stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

STI-571 in chronic myelogenous leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Chromosomal aberrations induced by double strand DNA breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Anaplastic large-cell lymphoma with rapid evolution to leukemic phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

A cell-based screen for resistance of Bcr-Abl-positive leukemia identifies the mutation pattern for PD166326, an alternative Abl kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

The two major imatinib resistance mutations E255K and T315I enhance the activity of BCR/ABL fusion kinase.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Reactive oxygen species-induced DNA damage and its modification: a chemical investigation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209756

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209756

1 reference

Dimensions Publication ID

14 August 2017

1047523434

0 references

Fatcat ID

release_5ults7fd6bgcfkwhqjuf4bgt2i

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/5ults7fd6bgcfkwhqjuf4bgt2i

24 November 2022

mapped directly with Wikidata item

1 reference