Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS. (Q36394283)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26621731%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26621731%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

1 March 2020

main subject

1 reference

1 reference

4

1 reference

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1 March 2020

Don W. Cleveland

14

1 reference

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1 March 2020

author name string

Shuying Sun

1

1 reference

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1 March 2020

Ying Sun

2

1 reference

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1 March 2020

Shuo-Chien Ling

3

1 reference

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1 March 2020

Melissa McAlonis-Downes

5

1 reference

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1 March 2020

Yiyang Zou

6

1 reference

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1 March 2020

Kevin Drenner

7

1 reference

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1 March 2020

Yin Wang

8

1 reference

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1 March 2020

Dara Ditsworth

9

1 reference

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1 March 2020

Seiya Tokunaga

10

1 reference

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1 March 2020

Alex Kopelevich

11

1 reference

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1 March 2020

Brian K Kaspar

12

1 reference

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1 March 2020

Clotilde Lagier-Tourenne

13

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1 March 2020

language of work or name

English

0 references

publication date

30 November 2015

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

1 March 2020

published in

1 reference

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1 March 2020

volume

112

1 reference

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1 March 2020

page(s)

E6993-7002

1 reference

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1 March 2020

issue

50

1 reference

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Macrophage migration inhibitory factor as a chaperone inhibiting accumulation of misfolded SOD1.

1 March 2020

cites work

1 reference

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Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations

30 September 2017

1 reference

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Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1.

30 September 2017

1 reference

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Microglial phagocytosis of live neurons

30 September 2017

1 reference

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Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

30 September 2017

1 reference

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Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

30 September 2017

1 reference

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Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

30 September 2017

1 reference

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Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models

30 September 2017

1 reference

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Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

30 September 2017

1 reference

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Functional contribution of the transcription factor ATF4 to the pathogenesis of amyotrophic lateral sclerosis

30 September 2017

1 reference

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A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model

30 September 2017

1 reference

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CaMKIIβ regulates oligodendrocyte maturation and CNS myelination

30 September 2017

1 reference

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Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis.

30 September 2017

1 reference

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Intricate interplay between astrocytes and motor neurons in ALS.

30 September 2017

1 reference

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RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Oligodendroglia metabolically support axons and contribute to neurodegeneration.

30 September 2017

1 reference

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Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS

30 September 2017

1 reference

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Genomic analysis of reactive astrogliosis

30 September 2017

1 reference

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Astrocytes and disease: a neurodevelopmental perspective

30 September 2017

1 reference

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Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages.

30 September 2017

1 reference

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

30 September 2017

1 reference

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Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

30 September 2017

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The unfolded protein response: from stress pathway to homeostatic regulation

30 September 2017

1 reference

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Dysregulation of astrocyte-motoneuron cross-talk in mutant superoxide dismutase 1-related amyotrophic lateral sclerosis

30 September 2017

1 reference

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Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Genomic and biochemical insights into the specificity of ETS transcription factors

30 September 2017

1 reference

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The unfolded protein response in familial amyotrophic lateral sclerosis

30 September 2017

1 reference

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NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.

30 September 2017

1 reference

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Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS

30 September 2017

1 reference

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Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

30 September 2017

1 reference

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Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

30 September 2017

1 reference

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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

30 September 2017

1 reference

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XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

30 September 2017

1 reference

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The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis

30 September 2017

1 reference

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TopHat: discovering splice junctions with RNA-Seq

30 September 2017

1 reference

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Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells

30 September 2017

1 reference

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Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation

30 September 2017

1 reference

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A translational profiling approach for the molecular characterization of CNS cell types

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Coordination of inflammation and metabolism by PPAR and LXR nuclear receptors

30 September 2017

1 reference

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ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Mapping and quantifying mammalian transcriptomes by RNA-Seq

30 September 2017

1 reference

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Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

30 September 2017

1 reference

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Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

30 September 2017

1 reference

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Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

30 September 2017

1 reference

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Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

30 September 2017

1 reference

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Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease

30 September 2017

1 reference

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Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS.

30 September 2017

1 reference

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Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons

30 September 2017

1 reference

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

30 September 2017

1 reference

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Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

30 September 2017

1 reference

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ETS transcription factors in endocrine systems

30 September 2017

1 reference

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

30 September 2017

1 reference

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ALS: a disease of motor neurons and their nonneuronal neighbors

30 September 2017

1 reference

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Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

30 September 2017

1 reference

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Onset and progression in inherited ALS determined by motor neurons and microglia

30 September 2017

1 reference

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Intrinsic capacities of molecular sensors of the unfolded protein response to sense alternate forms of endoplasmic reticulum stress

30 September 2017

1 reference

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Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

30 September 2017

1 reference

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Genome-wide identification of peroxisome proliferator response elements using integrated computational genomics

30 September 2017

1 reference

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PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

30 September 2017

1 reference

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No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model.

30 September 2017

1 reference

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PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

30 September 2017

1 reference

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

30 September 2017

1 reference

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The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

30 September 2017

1 reference

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The coregulator exchange in transcriptional functions of nuclear receptors

30 September 2017

1 reference

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

30 September 2017

1 reference

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

30 September 2017

1 reference

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Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity

30 September 2017

1 reference

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The PtdIns-PLC superfamily and signal transduction

30 September 2017

1 reference

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Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis

30 September 2017

1 reference

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Application of a translational profiling approach for the comparative analysis of CNS cell types

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice.

28 June 2018

1 reference

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ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

28 June 2018

1 reference

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SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice.

21 September 2018

1 reference

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CXCL10/CXCR3 signaling in glia cells differentially affects NMDA-induced cell death in CA and DG neurons of the mouse hippocampus.

21 September 2018

1 reference

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A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

21 September 2018

1 reference

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CXCL10-induced cell death in neurons: role of calcium dysregulation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Expression of an endoplasmic reticulum-resident chaperone, glucose-regulated stress protein 78, in the spinal cord of a mouse model of amyotrophic lateral sclerosis.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4687558

ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26621731

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1520639112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26621731%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26621731%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26621731%20AND%20SRC:MED&resulttype=core&format=json