Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS (Q30534614)

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English	Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS	scientific article

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scholarly article

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31 January 2020

Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS (English)

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31 January 2020

amyotrophic lateral sclerosis

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Concepción Lillo

4

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31 January 2020

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31 January 2020

Don W. Cleveland

13

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31 January 2020

author name string

Sandrine Da Cruz

1

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31 January 2020

Philippe A Parone

2

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Vanda S Lopes

3

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31 January 2020

Melissa McAlonis-Downes

5

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Sandra K Lee

6

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31 January 2020

Anne P Vetto

7

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Susanna Petrosyan

8

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Martin Marsala

9

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David S Williams

11

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31 January 2020

Bruce M Spiegelman

12

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publication date

1 May 2012

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31 January 2020

Cell Metabolism

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31 January 2020

15

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31 January 2020

5

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31 January 2020

778-786

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31 January 2020

describes a project that uses

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11 June 2022

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based on heuristic

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Misfolded SOD1 associated with motor neuron mitochondria alters mitochondrial shape and distribution prior to clinical onset.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons

1 reference

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20 June 2018

Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Mitochondrial dysfunction and intracellular calcium dysregulation in ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Oxidative stress sensitivity in ALS muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Onset and progression in inherited ALS determined by motor neurons and microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Metabolic control through the PGC-1 family of transcription coactivators

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

20 June 2018

Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565468

26 November 2018

Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22560226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

1 reference

https://pubmed.ncbi.nlm.nih.gov/22560226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22560226

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CMET.2012.03.019

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31 January 2020

1 reference

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31 January 2020

1 reference

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31 January 2020

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