The anti-death machinery in IKK/NF-kappaB signaling (Q36354713)

13 August 2017

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title

The anti-death machinery in IKK/NF-kappaB signaling (English)

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13 August 2017

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3

Michael Karin

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13 August 2017

Jun-Li Luo

1

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PubMed ID

16380818

13 August 2017

Hideaki Kamata

series ordinal

2

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PubMed ID

16380818

13 August 2017

language of work or name

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1 November 2005

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Journal of Clinical Immunology

13 August 2017

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13 August 2017

25

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13 August 2017

541-550

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13 August 2017

6

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https://scigraph.springernature.com/pub.10.1007/s10875-005-8217-6

13 August 2017

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cites work

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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12 December 2020

Cell survival and a Gadd45-factor deficiency

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12 December 2020

Caspase-independent cell death in T lymphocytes

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12 December 2020

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

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12 December 2020

NF-kappaB in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Cell death: the significance of apoptosis

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12 December 2020

c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration

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12 December 2020

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

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12 December 2020

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

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12 December 2020

Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

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12 December 2020

The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

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12 December 2020

Inhibitor of nuclear factor kB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic

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12 December 2020

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis

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12 December 2020

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

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12 December 2020

Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils

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12 December 2020

Mitochondria: releasing power for life and unleashing the machineries of death

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12 December 2020

More than one way to die: apoptosis, necrosis and reactive oxygen damage

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12 December 2020

Death and NF-kappaB in T cell activation: life at the edge

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12 December 2020

The CD95(APO-1/Fas) DISC and beyond

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12 December 2020

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

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12 December 2020

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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12 December 2020

Tumor necrosis factor and lymphotoxin: protection against oxidative stress through induction of MnSOD.

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12 December 2020

Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation

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12 December 2020

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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12 December 2020

Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD.

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12 December 2020

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

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12 December 2020

Caspases induce cytochrome c release from mitochondria by activating cytosolic factors

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12 December 2020

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

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12 December 2020

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

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12 December 2020

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria.

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12 December 2020

Apoptosis promotes a caspase-induced amino-terminal truncation of IkappaBalpha that functions as a stable inhibitor of NF-kappaB.

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12 December 2020

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule

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12 December 2020

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

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12 December 2020

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

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12 December 2020

NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK.

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12 December 2020

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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12 December 2020

c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions

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12 December 2020

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

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12 December 2020

Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

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12 December 2020

Blocking caspase-3-mediated proteolysis of IKKbeta suppresses TNF-alpha-induced apoptosis

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12 December 2020

Novel role for JNK as a stress-activated Bcl2 kinase

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12 December 2020

Cell death: critical control points

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12 December 2020

Two CD95 (APO-1/Fas) signaling pathways

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12 December 2020

Mammalian MAP kinase signalling cascades

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12 December 2020

Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy

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12 December 2020

JunD mediates survival signaling by the JNK signal transduction pathway.

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12 December 2020

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop

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12 December 2020

Reversible oxidation and inactivation of protein tyrosine phosphatases in vivo

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12 December 2020

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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12 December 2020

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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12 December 2020

Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha

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12 December 2020

Tumor necrosis factor: an apoptosis JuNKie?

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12 December 2020

To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis

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12 December 2020

IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

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12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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12 December 2020

Death receptor signaling

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12 December 2020

Reversible inactivation of protein-tyrosine phosphatase 1B in A431 cells stimulated with epidermal growth factor

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12 December 2020

Cytochrome c maintains mitochondrial transmembrane potential and ATP generation after outer mitochondrial membrane permeabilization during the apoptotic process

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12 December 2020

Caspase-independent cell killing by Fas-associated protein with death domain

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12 December 2020

Four deaths and a funeral: from caspases to alternative mechanisms.

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12 December 2020

AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-alpha in Jurkat leukemic cells

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12 December 2020

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

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12 December 2020

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

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12 December 2020

MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence.

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12 December 2020

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2.

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12 December 2020

Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase

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12 December 2020

Modulation of transcription factor NF-kappa B binding activity by oxidation-reduction in vitro

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12 December 2020

Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8

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12 December 2020

Superoxide dismutase as a target for the selective killing of cancer cells

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12 December 2020

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

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12 December 2020

The biochemistry of apoptosis

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12 December 2020

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4.

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12 December 2020

Fas-associated Death Domain Protein and Caspase-8 Are Not Recruited to the Tumor Necrosis Factor Receptor 1 Signaling Complex during Tumor Necrosis Factor-induced Apoptosis

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12 December 2020

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

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12 December 2020

The c-Rel transcription factor and B-cell proliferation: a deal with the devil

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12 December 2020

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

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12 December 2020

c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis

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12 December 2020

Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation

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12 December 2020

Reactive oxygen special (ROS), troublemakers between nuclear factor-kB (NF-kB) and c-Jun NH2-terminal kinase (JNK)

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12 December 2020

Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria

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12 December 2020

The IKK/NF-kappa B pathway

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12 December 2020

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

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12 December 2020

Protein-based therapeutic approaches targeting death receptors

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12 December 2020

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

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12 December 2020

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

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12 December 2020

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

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12 December 2020

Caspase activation is not death

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12 December 2020

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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12 December 2020

Targeting NF-kappaB activation via pharmacologic inhibition of IKK2-induced apoptosis of human acute myeloid leukemia cells.

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12 December 2020

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

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12 December 2020

Redox regulation of cellular signalling

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12 December 2020

High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation

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12 December 2020

Linking JNK signaling to NF-kappaB: a key to survival

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12 December 2020

NF-kappaB at the crossroads of life and death

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12 December 2020

Signal transduction by the JNK group of MAP kinases

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12 December 2020

Death without caspases, caspases without death

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12 December 2020

Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila

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12 December 2020

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

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12 December 2020

The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant

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12 December 2020

JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins

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12 December 2020

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

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12 December 2020

Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.

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12 December 2020

Caspase-8 serves both apoptotic and nonapoptotic roles

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12 December 2020

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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12 December 2020

Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression

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12 December 2020

T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes

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12 December 2020

Genome wide analysis of TNF-inducible genes reveals that antioxidant enzymes are induced by TNF and responsible for elimination of ROS.

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12 December 2020

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

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12 December 2020

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

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12 December 2020

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

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12 December 2020

TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

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12 December 2020

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices

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12 December 2020

Missing pieces in the NF-kappaB puzzle

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12 December 2020

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

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12 December 2020

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

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12 December 2020

Roles of MAPKKK ASK1 in stress-induced cell death.

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12 December 2020

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

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12 December 2020

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

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12 December 2020

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

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12 December 2020

Inhibition of JNK activation through NF-kappaB target genes

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12 December 2020

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

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12 December 2020

10.1007/S10875-005-8217-6

Identifiers

DOI

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13 August 2017

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PubMed ID

16380818