Missing pieces in the NF-kappaB puzzle (Q29547864)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983155%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

title

Missing pieces in the NF-kappaB puzzle (English)

2 references

PubMed

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11983155

23 April 2017

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10 December 2019

0 references

1

1 reference

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10 December 2019

author name string

Michael Karin

series ordinal

2

1 reference

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10 December 2019

publication date

1 April 2002

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10 December 2019

language of work or name

1 reference

23 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11983155

23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983155%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

volume

109 Suppl

2 references

PubMed

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23 April 2017

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10 December 2019

page(s)

S81-96

2 references

PubMed

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23 April 2017

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publication type of scholarly work

10 December 2019

review article

1 reference

Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment

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Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells

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The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

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Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor

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Series introduction: the transcription factor NF-kappaB and human disease

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

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Regulatory functions of ubiquitination in the immune system

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Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit

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PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

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Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

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Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

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Persistent activation of NF-kappa B by the tax transforming protein involves chronic phosphorylation of IkappaB kinase subunits IKKbeta and IKKgamma

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Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

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An exceptionally well-preserved theropod dinosaur from the Yixian Formation of China

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A novel DNA recognition mode by the NF-κB p65 homodimer

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

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TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

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Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta

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7 January 2021

Autoregulation of I kappa B alpha activity

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7 January 2021

JNK2 and IKKbeta are required for activating the innate response to viral infection

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7 January 2021

DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.

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7 January 2021

Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U

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7 January 2021

The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators

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7 January 2021

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

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Kinase regulation in inflammatory response

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Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

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7 January 2021

The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

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7 January 2021

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

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7 January 2021

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

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7 January 2021

Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system

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7 January 2021

Hsp90 is required for c-Mos activation and biphasic MAP kinase activation in Xenopus oocytes

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7 January 2021

Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture

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The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues

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Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation

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CREB-binding protein/p300 are transcriptional coactivators of p65

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Structure of NF-kappa B p50 homodimer bound to a kappa B site

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1.

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The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

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The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression

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7 January 2021

Regulation of RelA subcellular localization by a putative nuclear export signal and p50.

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7 January 2021

A Toll-like receptor recognizes bacterial DNA

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7 January 2021

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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7 January 2021

CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation

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7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

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7 January 2021

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

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7 January 2021

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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7 January 2021

IKKalpha controls formation of the epidermis independently of NF-kappaB.

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7 January 2021

A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes

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7 January 2021

X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2

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7 January 2021

The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation

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7 January 2021

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

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7 January 2021

Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

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7 January 2021

Structure of an IkappaBalpha/NF-kappaB complex

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An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha

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IkappaB kinase alpha is essential for mature B cell development and function

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NF-kappa B subunit regulation in nontransformed CD4+ T lymphocytes

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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NF-kappaB at the crossroads of life and death

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The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

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The physical association of protein kinase C theta with a lipid raft-associated inhibitor of kappa B factor kinase (IKK) complex plays a role in the activation of the NF-kappa B cascade by TCR and CD28.

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7 January 2021

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

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7 January 2021

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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The Toll-receptor family and control of innate immunity

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Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor

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7 January 2021

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

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7 January 2021

CIKS, a connection to Ikappa B kinase and stress-activated protein kinase

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Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

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7 January 2021

IKK1-deficient mice exhibit abnormal development of skin and skeleton

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7 January 2021

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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7 January 2021

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

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7 January 2021

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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7 January 2021

NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176

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7 January 2021

Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway

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7 January 2021

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

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7 January 2021

Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

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7 January 2021

Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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7 January 2021

IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells

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7 January 2021

Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

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7 January 2021

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

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7 January 2021

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

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7 January 2021

Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation

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7 January 2021

Structure of the NF-kappa B p50 homodimer bound to DNA

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7 January 2021

Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen

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7 January 2021

Evidence for a role of CRM1 in signal-mediated nuclear protein export

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7 January 2021

Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator

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7 January 2021

Mechanism of kappa B DNA binding by Rel/NF-kappa B dimers

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7 January 2021

KBF1 (p50 NF-kappa B homodimer) acts as a repressor of H-2Kb gene expression in metastatic tumor cells

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7 January 2021

Identification and characterization of an IkappaB kinase

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7 January 2021

Inducible NF-kappaB activation is permitted by simultaneous degradation of nuclear IkappaBalpha

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7 January 2021

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

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7 January 2021

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

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7 January 2021

Nuclear Localization of IκBα Is Mediated by the Second Ankyrin Repeat: the IκBα Ankyrin Repeats Define a Novel Class of cis-Acting Nuclear Import Sequences

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7 January 2021

Modulation of Akt kinase activity by binding to Hsp90

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7 January 2021

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

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7 January 2021

NEMO/IKK gamma-deficient mice model incontinentia pigmenti

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7 January 2021

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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7 January 2021

IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

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7 January 2021

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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7 January 2021

Transcriptional activation by NF-kappaB requires multiple coactivators

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7 January 2021

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

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7 January 2021

NF-kappaB signaling pathways in mammalian and insect innate immunity

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7 January 2021

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

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7 January 2021

RelB Cellular Regulation and Transcriptional Activity Are Regulated by p100

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7 January 2021

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

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7 January 2021

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Limb and skin abnormalities in mice lacking IKKalpha

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

IkappaB family members function by different mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

NAK is an IkappaB kinase-activating kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Characterization of IκBα Nuclear Import Pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

The essential role of MEKK3 in TNF-induced NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

Phosphorylation of NF-κB p65 by PKA Stimulates Transcriptional Activity by Promoting a Novel Bivalent Interaction with the Coactivator CBP/p300

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900703-1

7 January 2021

10.1016/S0092-8674(02)00703-1

Identifiers

DOI

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983155%20AND%20SRC:MED&resulttype=core&format=json

10 December 2019

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=11983155

3 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11983155%20AND%20SRC:MED&resulttype=core&format=json