JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis (Q24554008)

PubMed

PubMed publication ID

12591950

19 October 2023

Roger J Davis

series ordinal

2

author given names

Roger J

author last names

Davis

1 reference

PubMed

PubMed publication ID

12591950

Proceedings of the National Academy of Sciences of the United States of America

19 October 2023

publication date

4 March 2003

0 references

language of work or name

English

0 references

published in

0 references

volume

100

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issue

5

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page(s)

2432-7

0 references

cites work

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

24 March 2017

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24 March 2017

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Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim

24 March 2017

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The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

24 March 2017

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Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl‐2 family1

24 March 2017

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

24 March 2017

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Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

24 March 2017

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Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

24 March 2017

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

24 March 2017

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

24 March 2017

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Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

24 March 2017

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

24 March 2017

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Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

24 March 2017

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A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

24 March 2017

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

7 April 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

7 April 2017

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Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress

7 April 2017

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JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery

27 September 2017

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Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

27 September 2017

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Activation of the p53 tumor suppressor protein

27 September 2017

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BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death.

27 September 2017

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FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151358

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151358

Signal transduction by MAP kinases in T lymphocytes

27 September 2017

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Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitors

27 September 2017

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27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151358

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151358

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151358

Role of the Jun Kinase Pathway in the Regulation of c-Jun Expression and Apoptosis in Sympathetic Neurons

27 September 2017

1 reference

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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151358

Ordering the cell death pathway. Differential effects of BCL2, an interleukin-1-converting enzyme family protease inhibitor, and other survival agents on JNK activation in serum/nerve growth factor-deprived PC12 cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=151358

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12591950

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0438011100

1 reference

release_3ialoew5lfdhjl2hxnpz4biguq

0 references

0 references

827244

1 reference

1 reference

827244

PubMed publication ID

12591950

1 reference