Novel C-1 substituted cocaine analogs unlike cocaine or benztropine. (Q36335545)

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11 February 2020

title

Novel C-1 substituted cocaine analogs unlike cocaine or benztropine (English)

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8

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author name string

Maarten E A Reith

1

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11 February 2020

Solav Ali

2

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11 February 2020

Audrey Hashim

3

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11 February 2020

Imran S Sheikh

4

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11 February 2020

Naresh Theddu

5

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11 February 2020

Narendra V Gaddiraju

6

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11 February 2020

Suneet Mehrotra

7

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Thomas F Murray

9

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11 February 2020

Henry Sershen

10

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11 February 2020

Ellen M Unterwald

11

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11 February 2020

Franklin A Davis

12

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11 February 2020

language of work or name

English

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publication date

15 August 2012

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Journal of Pharmacology and Experimental Therapeutics

11 February 2020

published in

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volume

343

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issue

2

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11 February 2020

page(s)

413-425

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Enantioselective synthesis of cocaine C-1 analogues using sulfinimines (N-sulfinyl imines).

11 February 2020

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A Role for Sigma Receptors in Stimulant Self Administration and Addiction.

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Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors

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Cocaine locomotor activation, sensitization and place preference in six inbred strains of mice

30 September 2017

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Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents.

30 September 2017

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The substrate-driven transition to an inward-facing conformation in the functional mechanism of the dopamine transporter

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N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects

30 September 2017

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The binding sites for benztropines and dopamine in the dopamine transporter overlap.

30 September 2017

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Substrate and drug binding sites in LeuT.

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Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies

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Bivalent phenethylamines as novel dopamine transporter inhibitors: evidence for multiple substrate-binding sites in a single transporter.

30 September 2017

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Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels

30 September 2017

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Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter

30 September 2017

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Interaction of cocaine-, benztropine-, and GBR12909-like compounds with wild-type and mutant human dopamine transporters: molecular features that differentially determine antagonist-binding properties.

30 September 2017

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The binding sites for cocaine and dopamine in the dopamine transporter overlap

30 September 2017

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D-161, a novel pyran-based triple monoamine transporter blocker: behavioral pharmacological evidence for antidepressant-like action

30 September 2017

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Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons

30 September 2017

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The principles of agonist pharmacotherapy for psychostimulant dependence

30 September 2017

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Computation of octanol-water partition coefficients by guiding an additive model with knowledge

30 September 2017

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Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors

30 September 2017

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Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction

30 September 2017

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LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake

30 September 2017

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Adventures in sulfur-nitrogen chemistry

30 September 2017

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Balance between dopamine and serotonin release modulates behavioral effects of amphetamine-type drugs

30 September 2017

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30 September 2017

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Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter

30 September 2017

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The mesolimbic dopamine reward circuit in depression

30 September 2017

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30 September 2017

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30 September 2017

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Mutation of Trp84 and Asp313 of the dopamine transporter reveals similar mode of binding interaction for GBR12909 and benztropine as opposed to cocaine.

30 September 2017

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Conditioned place preference: what does it add to our preclinical understanding of drug reward?

30 September 2017

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Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium

30 September 2017

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Characterization of a recombinant human dopamine transporter in multiple cell lines

30 September 2017

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Rate of binding of various inhibitors at the dopamine transporter in vivo

30 September 2017

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Compounds Affecting the Central Nervous System. 4. 3.beta.-Phenyltropane-2-carboxylic Esters and Analogs

30 September 2017

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Cocaine receptor: biochemical characterization and structure-activity relationships of cocaine analogues at the dopamine transporter

30 September 2017

1 reference

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Behavioral effects of novel cocaine analogs: a comparison with in vivo receptor binding potency

30 September 2017

1 reference

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Drug delivery to the brain: barrier modification and drug modification methodologies

30 September 2017

1 reference

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Behavioral despair in mice: a primary screening test for antidepressants

30 September 2017

1 reference

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The uptake inhibitors cocaine and benztropine differentially alter the conformation of the human dopamine transporter

30 September 2017

1 reference

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Separation of the locomotor stimulant and discriminative stimulus effects of cocaine by its C-2 phenyl ester analog, RTI-15.

29 June 2018

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Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.

29 June 2018

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Inhibition of synaptosomal veratridine-induced sodium influx by antidepressants and neuroleptics used in chronic pain.

29 June 2018

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Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence.

29 June 2018

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Structural requirements for cocaine congeners to interact with dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior.

29 June 2018

1 reference

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Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice.

29 June 2018

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Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice.

29 June 2018

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Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice.

29 June 2018

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Asymmetric total synthesis of (S)-(+)-cocaine and the first synthesis of cocaine C-1 analogs from N-sulfinyl β-amino ester ketals

22 September 2018

1 reference

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Does dual antidepressant therapy as initial treatment hasten and increase remission from depression?

22 September 2018

1 reference

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Identification of a dopamine transporter ligand that blocks the stimulant effects of cocaine.

22 September 2018

1 reference

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Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands

22 September 2018

1 reference

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Strain and sex differences in repeated ethanol treatment-induced motor activity in quasi-congenic mice

22 September 2018

1 reference

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Modification of behavioral effects of cocaine by selective serotonin and dopamine uptake inhibitors in squirrel monkeys.

22 September 2018

1 reference

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Interactions of cocaine and cocaine congeners with sodium channels

22 September 2018

1 reference

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22 September 2018

Identifiers

DOI

10.1124/JPET.112.193771

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895898%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895898%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

22895898

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22895898%20AND%20SRC:MED&resulttype=core&format=json