PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways (Q36328818)

13 August 2017

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title

PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways (English)

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13 August 2017

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J Moscat

1

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PubMed ID

16322752

13 August 2017

P Rennert

series ordinal

2

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PubMed ID

16322752

13 August 2017

M T Diaz-Meco

series ordinal

3

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13 August 2017

1 May 2006

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Cell Death & Differentiation

13 August 2017

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13 August 2017

13

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13 August 2017

702-711

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13 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401823

13 August 2017

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cites work

The extended protein kinase C superfamily

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

NF-kappaB activation by protein kinase C isoforms and B-cell function

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

PRK1 is targeted to endosomes by the small GTPase, RhoB

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Protein kinase C zeta isoform is critical for mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Missing pieces in the NF-kappaB puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Inhibition of JNK activation through NF-kappaB target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Regulation of mature T lymphocyte proliferation and differentiation by Par-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Transcriptional regulation by the phosphorylation-dependent factor CREB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The immune response of Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The two NF-kappaB activation pathways and their role in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Nuclear factor kappa B is required for the development of marginal zone B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The TNF and TNF receptor superfamilies: integrating mammalian biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Role of zeta PKC in B-cell signaling and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Regulation of JAK-STAT signalling in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The lineage decisions of helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

T cell receptor signaling: beyond complex complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Control of T helper 2 cell function and allergic airway inflammation by PKCzeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

New insights into the pathogenesis of asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Tumor Necrosis Factor-α Induces Early-Onset Endothelial Adhesivity by Protein Kinase Cζ–Dependent Activation of Intercellular Adhesion Molecule-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Crucial role of IL-4/STAT6 in T cell-mediated hepatitis: up-regulating eotaxins and IL-5 and recruiting leukocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Interaction of protein kinase C zeta with ZIP, a novel protein kinase C-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

OPR, PC and AID: all in the PB1 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

PB1 domain-mediated heterodimerization in NADPH oxidase and signaling complexes of atypical protein kinase C with Par6 and p62

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Cell polarity: Par6, aPKC and cytoskeletal crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

RANK-L and RANK: T cells, bone loss, and mammalian evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

TRAF2: a double-edged sword?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Immunodeficiency in protein kinase cbeta-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Tumour-suppression activity of the proapoptotic regulator Par4.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Immunology. Opposites attract in differentiating T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Differential regulation of Th2 and Th1 lung inflammatory responses by protein kinase C theta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

New insights into the pathogenesis of asthma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Par proteins: partners in polarization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401823

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401823

1 reference

13 August 2017

1 reference

PubMed ID

16322752