Transcriptional regulation by the phosphorylation-dependent factor CREB (Q28210623)

Nature Reviews Molecular Cell Biology

Europe PubMed Central

title

Transcriptional regulation by the phosphorylation-dependent factor CREB (English)

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B Mayr

1

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author name string

M Montminy

series ordinal

2

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language of work or name

English

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publication date

August 2001

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published in

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volume

2

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page(s)

599-609

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issue

8

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cites work

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

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7 January 2021

Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.

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7 January 2021

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene

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7 January 2021

A cyclic AMP- and phorbol ester-inducible DNA element

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7 January 2021

Phosphorylated CREB binds specifically to the nuclear protein CBP

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7 January 2021

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

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7 January 2021

Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.

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7 January 2021

Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation

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7 January 2021

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA

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7 January 2021

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

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7 January 2021

CREM gene: use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

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7 January 2021

Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers

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7 January 2021

Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors

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7 January 2021

More is better: Activators and repressors from the same gene

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7 January 2021

Inducibility and negative autoregulation of CREM: an alternative promoter directs the expression of ICER, an early response repressor.

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7 January 2021

The inducible cyclic adenosine monophosphate early repressor (ICER) in the pituitary intermediate lobe: role in the stress response

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7 January 2021

Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein

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7 January 2021

Severe impairment of spermatogenesis in mice lacking the CREM gene

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7 January 2021

Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice

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7 January 2021

Altered emotional and locomotor responses in mice deficient in the transcription factor CREM

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7 January 2021

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

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7 January 2021

Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant

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7 January 2021

PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling

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7 January 2021

Cell cycle regulation of cyclin A gene expression by the cyclic AMP-responsive transcription factors CREB and CREM.

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7 January 2021

pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-

1 reference

7 January 2021

The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.

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7 January 2021

Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons

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7 January 2021

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms

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7 January 2021

Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

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7 January 2021

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB.

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7 January 2021

CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation

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7 January 2021

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein.

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7 January 2021

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

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7 January 2021

CREB as a memory modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in Drosophila

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7 January 2021

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

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7 January 2021

The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer

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7 January 2021

Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties

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7 January 2021

Structure/function relationship of the cAMP response element in tyrosine hydroxylase gene transcription.

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7 January 2021

Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element

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7 January 2021

Sequential serum-dependent activation of CREB and NRF-1 leads to enhanced mitochondrial respiration through the induction of cytochrome c.

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7 January 2021

Control of cAMP-regulated enhancers by the viral transactivator Tax through CREB and the co-activator CBP.

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7 January 2021

A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos

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7 January 2021

cAMP response element-binding protein monomers cooperatively assemble to form dimers on DNA.

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7 January 2021

DNA specificity enhanced by sequential binding of protein monomers.

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7 January 2021

The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding

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7 January 2021

Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro

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7 January 2021

In vivo monitoring of a cAMP-stimulated DNA-binding activity

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7 January 2021

In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1

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7 January 2021

Interferon-gamma-mediated inhibition of cyclin A gene transcription is independent of individual cis-acting elements in the cyclin A promoter

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7 January 2021

The AP-1 Site and the cAMP- and Serum Response Elements of the c-fosGene Are Constitutively OccupiedIn Vivo

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7 January 2021

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation

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7 January 2021

Methylation of transcription factor binding sites in the Epstein-Barr virus latent cycle promoter Wp coincides with promoter down-regulation during virus-induced B-cell transformation

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7 January 2021

Methylation-dependent silencing of the testis-specific Pdha-2 basal promoter occurs through selective targeting of an activating transcription factor/cAMP-responsive element-binding site.

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7 January 2021

Regulation of Pdha-2 expression is mediated by proximal promoter sequences and CpG methylation

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7 January 2021

Conformation of Tax-response elements in the human T-cell leukemia virus type I promoter

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7 January 2021

Sequences flanking the cAMP responsive core of the HTLV-I tax response elements influence CREB protease sensitivity.

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7 January 2021

The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove

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7 January 2021

Analysis of a cAMP-responsive activator reveals a two-component mechanism for transcriptional induction via signal-dependent factors

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7 January 2021

Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators

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7 January 2021

The CREB constitutive activation domain interacts with TATA-binding protein-associated factor 110 (TAF110) through specific hydrophobic residues in one of the three subdomains required for both activation and TAF110 binding

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7 January 2021

The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex

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7 January 2021

A glutamine-rich hydrophobic patch in transcription factor Sp1 contacts the dTAFII110 component of the Drosophila TFIID complex and mediates transcriptional activation

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7 January 2021

Distinct cAMP response element-binding protein (CREB) domains stimulate different steps in a concerted mechanism of transcription activation

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7 January 2021

Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation

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7 January 2021

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

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7 January 2021

Nuclear protein CBP is a coactivator for the transcription factor CREB

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7 January 2021

Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism

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7 January 2021

Adaptor-mediated recruitment of RNA polymerase II to a signal-dependent activator

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7 January 2021

Transcription factor-specific requirements for coactivators and their acetyltransferase functions

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7 January 2021

Solution Structure of the KIX Domain of CBP Bound to the Transactivation Domain of CREB: A Model for Activator:Coactivator Interactions

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7 January 2021

CBP-independent activation of CREM and CREB by the LIM-only protein ACT

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7 January 2021

A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM

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7 January 2021

Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP.

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7 January 2021

Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals.

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7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

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7 January 2021

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

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7 January 2021

Differential activation of CREB by Ca2+/calmodulin-dependent protein kinases type II and type IV involves phosphorylation of a site that negatively regulates activity

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7 January 2021

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression

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7 January 2021

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene

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7 January 2021

MSK1 is required for CREB phosphorylation in response to mitogens in mouse embryonic stem cells

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7 January 2021

L-type voltage-sensitive Ca2+ channel activation regulates c-fos transcription at multiple levels

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7 January 2021

Stimulus-specific interaction between activator-coactivator cognates revealed with a novel complex-specific antiserum

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7 January 2021

CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.

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7 January 2021

Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo

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7 January 2021

Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation

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7 January 2021

Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation

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7 January 2021

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

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7 January 2021

MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation

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7 January 2021

Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. Involvement of p38 mitogen-activated protein kinase-mediated pathway.

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7 January 2021

Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation

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7 January 2021

Mechanical control of cyclic AMP signalling and gene transcription through integrins

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7 January 2021

Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells

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7 January 2021

Identifiers

DOI

10.1038/35085068

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

538219

1024796022

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538219

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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