Selecting and maintaining a diverse T-cell repertoire (Q33783983)

29 July 2017

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title

Selecting and maintaining a diverse T-cell repertoire (English)

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29 July 2017

Goldrath AW

1

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29 July 2017

Bevan MJ

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

402

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29 July 2017

255-262

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29 July 2017

6759

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https://scigraph.springernature.com/pub.10.1038/46218

29 July 2017

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Positive selection of thymocytes

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Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues

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Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids

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Structural basis of T cell recognition

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Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes

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Early alpha beta T cell development in the thymus of normal and genetically altered mice

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Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

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The MHC reactivity of the T cell repertoire prior to positive and negative selection.

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How many thymocytes audition for selection?

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Control of MHC restriction by TCR Valpha CDR1 and CDR2

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Thymic skewing of the CD4/CD8 ratio maps with the T-cell receptor alpha-chain locus

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Quantitative impact of thymic clonal deletion on the T cell repertoire

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Selective events in T cell development

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Role of self-peptides in positively selecting the T-cell repertoire

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Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding

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Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture

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Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

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Evidence for a differential avidity model of T cell selection in the thymus

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T cell receptor antagonist peptides induce positive selection

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Mature T cell reactivity altered by peptide agonist that induces positive selection

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Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

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Ligand recognition by alpha beta T cell receptors

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Immunology. An affinity for learning.

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Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes

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A T cell receptor-specific blockade of positive selection

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Essential flexibility in the T-cell recognition of antigen

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Antigen presentation and T cell development in H2-M-deficient mice

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H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

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Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

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Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice

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Thymic selection by a single MHC/peptide ligand produces a semidiverse repertoire of CD4+ T cells.

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The imprint of intrathymic self-peptides on the mature T cell receptor repertoire

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Requirement for diverse, low-abundance peptides in positive selection of T cells

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Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

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Divergent changes in the sensitivity of maturing T cells to structurally related ligands underlies formation of a useful T cell repertoire

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Lymphocyte homeostasis

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Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages

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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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CD4+ T cell division in irradiated mice requires peptides distinct from those responsible for thymic selection

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The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools

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Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

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The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

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The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool

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Peripheral selection of T cell repertoires: the role of continuous thymus output

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Lifespans of naive, memory and effector lymphocytes

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Mature murine B and T cells transferred to SCID mice can survive indefinitely and many maintain a virgin phenotype

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Turnover of naive- and memory-phenotype T cells

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Cell division in the compartment of naive and memory T lymphocytes.

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The transcription factor NFAT4 is involved in the generation and survival of T cells

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IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

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The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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Peripheral T cell survival

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Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules

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7 January 2021

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

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Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells

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7 January 2021

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses

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7 January 2021

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

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7 January 2021

Persistence of memory CD8 T cells in MHC class I-deficient mice

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7 January 2021

Post- thymic in vivo expansion of mature alpha beta T cells

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Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?

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Fate of T and B cells transferred to SCID mice

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7 January 2021

The peripheral T-cell pool: regulation by non-antigen induced proliferation?

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7 January 2021

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition

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7 January 2021

TCR-MHC class II interaction is required for peripheral expansion of CD4 cells in a T cell-deficient host.

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7 January 2021

Homeostatic expansion and phenotypic conversion of naïve T cells in response to self peptide/MHC ligands

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7 January 2021

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

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7 January 2021

Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules

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7 January 2021

Following the development of a CD4 T cell response in vivo: from activation to memory formation.

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Class II-independent generation of CD4 memory T cells from effectors.

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7 January 2021

Massive expansion of antigen-specific CD8+ T cells during an acute virus infection

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7 January 2021

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

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Coordinate regulation of complex T cell populations responding to bacterial infection.

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7 January 2021

Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo

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7 January 2021

Antigen-specific CD8+ T cell subset distribution in lymph nodes draining the site of herpes simplex virus infection

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7 January 2021

Virus-specific CD8+ T cells in primary and secondary influenza pneumonia

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7 January 2021

Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection

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Modelling T-cell memory by genetic marking of memory T cells in vivo

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7 January 2021

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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7 January 2021

Identifiers

DOI

10.1038/46218

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Dimensions Publication ID

29 July 2017

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