What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity? (Q35196417)

7 August 2017

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title

What do TCR-pMHC crystal structures teach us about MHC restriction and alloreactivity? (English)

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7 August 2017

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2

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7 August 2017

Dominique Housset

1

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PubMed ID

12909456

7 August 2017

language of work or name

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1 August 2003

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7 August 2017

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7 August 2017

24

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7 August 2017

8

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7 August 2017

429-437

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Thymic selection revisited: how essential is it?

7 August 2017

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7 January 2021

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

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7 January 2021

An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex

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7 January 2021

Structure of the complex between human T-cell receptor, viral peptide and HLA-A2

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7 January 2021

Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids

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7 January 2021

Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical

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7 January 2021

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

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7 January 2021

Crystal structure of a T cell receptor bound to an allogeneic MHC molecule

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7 January 2021

A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex

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7 January 2021

Structural Comparison of Allogeneic and Syngeneic T Cell Receptor–Peptide-Major Histocompatibility Complex Complexes

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7 January 2021

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

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7 January 2021

CDR3 loop flexibility contributes to the degeneracy of TCR recognition

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7 January 2021

The crystal structure of a T cell receptor in complex with peptide and MHC class II

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7 January 2021

Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1

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7 January 2021

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7 January 2021

The specificity of TCR/pMHC interaction

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7 January 2021

Structural and thermodynamic correlates of T cell signaling

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7 January 2021

Structural basis of T cell recognition of peptides bound to MHC molecules

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7 January 2021

Not just any T cell receptor will do.

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7 January 2021

A very high level of crossreactivity is an essential feature of the T-cell receptor

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7 January 2021

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen

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7 January 2021

Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor

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7 January 2021

TCR binding to peptide-MHC stabilizes a flexible recognition interface

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7 January 2021

Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning

1 reference

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7 January 2021

An evolutionary and structural perspective on T cell antigen receptor function

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7 January 2021

Antibody multispecificity mediated by conformational diversity

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7 January 2021

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

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7 January 2021

The three-dimensional structure of a T-cell antigen receptor V alpha V beta heterodimer reveals a novel arrangement of the V beta domain

1 reference

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7 January 2021

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

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7 January 2021

How many thymocytes audition for selection?

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7 January 2021

Predominant role of T cell receptor (TCR)-alpha chain in forming preimmune TCR repertoire revealed by clonal TCR reconstitution system

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7 January 2021

Structural Basis of Cytochrome c Presentation by IE k

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7 January 2021

Are MHC-bound peptides a nuisance for positive selection?

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7 January 2021

Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes

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7 January 2021

The Shaping of the T Cell Repertoire

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7 January 2021

Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

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7 January 2021

Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove

1 reference

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7 January 2021

Population biology of antigen presentation by MHC class I molecules

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7 January 2021

High determinant density may explain the phenomenon of alloreactivity

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7 January 2021

Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

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7 January 2021

Presidential Address to The American Association of Immunologists: Major Histocompatibility Complex Proteins and TCRs: Do They Really Go Together Like a Horse and Carriage?

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7 January 2021

Comparative analysis of the CD8(+) T cell repertoires of H-2 class I wild-type/HLA-A2.1 and H-2 class I knockout/HLA-A2.1 transgenic mice

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7 January 2021

The role of peptides in T cell alloreactivity is determined by self-major histocompatibility complex molecules

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7 January 2021

Tritope model of restrictive recognition by the TCR.

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7 January 2021

Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors

1 reference

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7 January 2021

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

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7 January 2021

Role of 2CT cell receptor residues in the binding of self- and allo-major histocompatibility complexes

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7 January 2021

Unraveling hot spots in binding interfaces: progress and challenges

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7 January 2021

Characterizing transition states in protein folding: an essential step in the puzzle

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7 January 2021

Structure of the transition state for folding of a protein derived from experiment and simulation

1 reference

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7 January 2021

A mutational analysis of binding interactions in an antigen-antibody protein-protein complex

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7 January 2021

Binding of small molecules to an adaptive protein-protein interface

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7 January 2021

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

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7 January 2021

Raster3D: photorealistic molecular graphics

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7 January 2021

Crystal structure of the beta chain of a T cell antigen receptor

1 reference

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7 January 2021

Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody

1 reference

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7 January 2021

Crystal structure of the V alpha domain of a T cell antigen receptor

1 reference

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7 January 2021

Use of H-2 mutations to quantitate alloreactivity: Alloreactivity is strongest against H-2 antigens which are closet to self

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7 January 2021

Canonical structures for the hypervariable regions of T cell alphabeta receptors

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https://api.crossref.org/works/10.1016%2FS1471-4906%2803%2900180-7

7 January 2021

10.1016/S1471-4906(03)00180-7

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12909456