NF-kappaB regulation in the immune system (Q28205043)

Nature Reviews Immunology

Europe PubMed Central

title

NF-kappaB regulation in the immune system (English)

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Qiutang Li

1

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Inder M Verma

series ordinal

2

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language of work or name

English

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publication date

October 2002

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published in

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volume

2

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page(s)

725-34

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issue

10

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cites work

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Rel/NF-kappa B and I kappa B proteins: an overview

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NF-kappaB signaling pathways in mammalian and insect innate immunity

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The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators

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The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation

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Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus.

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Postrepression activation of NF-kappaB requires the amino-terminal nuclear export signal specific to IkappaBalpha

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An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha

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A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes

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IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells

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Characterization of the nuclear import and export functions of Ikappa B(epsilon).

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IkappaB family members function by different mechanisms

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A subclass of Ras proteins that regulate the degradation of IkappaB

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Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

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Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta

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Toll-like receptors: critical proteins linking innate and acquired immunity

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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The essential role of MEKK3 in TNF-induced NF-kappaB activation

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Protein kinase C-theta;: signaling from the center of the T-cell synapse

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

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Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure

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Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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Regulatory functions of ubiquitination in the immune system

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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IKKalpha controls formation of the epidermis independently of NF-kappaB.

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IKK1-deficient mice exhibit abnormal development of skin and skeleton

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Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

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Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium

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X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling

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NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF

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Activation of the Ikappa B kinases by RIP via IKKgamma /NEMO-mediated oligomerization

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Sites on FIP-3 (NEMO/IKKgamma) essential for its phosphorylation and NF-kappaB modulating activity

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Persistent activation of NF-kappa B by the tax transforming protein involves chronic phosphorylation of IkappaB kinase subunits IKKbeta and IKKgamma

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TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90

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IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2

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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

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MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation

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MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

31 March 2020

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Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice.

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NAK is an IkappaB kinase-activating kinase

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TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

31 March 2020

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Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

31 March 2020

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Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

31 March 2020

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Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II

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IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

31 March 2020

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

31 March 2020

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Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway

31 March 2020

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Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics.

31 March 2020

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Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor

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Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

31 March 2020

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The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

31 March 2020

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Duration of nuclear NF-kappaB action regulated by reversible acetylation

31 March 2020

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The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

31 March 2020

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Enhancement of nuclear factor-kappa B acetylation by coactivator p300 and HIV-1 Tat proteins.

31 March 2020

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The Rel/NF-kappa B family: friend and foe.

31 March 2020

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The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation.

31 March 2020

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Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

31 March 2020

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IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

31 March 2020

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Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

31 March 2020

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NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.

31 March 2020

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NF-kappa B/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells

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A critical role for the RelA subunit of nuclear factor kappaB in regulation of multiple immune-response genes and in Fas-induced cell death

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Requirement for NF-kappaB in osteoclast and B-cell development

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IkappaB kinase alpha is essential for mature B cell development and function

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An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis

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NF-kappaB: a key role in inflammatory diseases

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Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammation

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Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators

31 March 2020

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NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

31 March 2020

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Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

31 March 2020

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Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

31 March 2020

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A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats

31 March 2020

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High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation

31 March 2020

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Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

31 March 2020

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NF-kappa B regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes

31 March 2020

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Distinct roles for the NF-kappaB1 (p50) and c-Rel transcription factors in inflammatory arthritis

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI910

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Consolidated OpenCitations Corpus – April 2017

235503

235503

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

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