NF-kappa B: arresting a major culprit in cancer (Q34731415)

4 August 2017

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title

NF-kappa B: arresting a major culprit in cancer (English)

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4 August 2017

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Burkhard Haefner

1

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4 August 2017

1 June 2002

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4 August 2017

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4 August 2017

7

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4 August 2017

653-663

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4 August 2017

12

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NF-kappaB in cancer: from innocent bystander to major culprit

4 August 2017

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7 January 2021

Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

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7 January 2021

Chronic immune activation and inflammation as the cause of malignancy

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7 January 2021

Inflammation and cancer: back to Virchow?

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7 January 2021

Plasma levels of tumour necrosis factor and its soluble receptors correlate with clinical features and outcome of Hodgkin's disease patients.

1 reference

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7 January 2021

Paradoxical effects of tumour necrosis factor in experimental ovarian cancer

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7 January 2021

NSAIDs and gastrointestinal cancer prevention

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7 January 2021

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Aberrant rel/nfkb genes and activity in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Oncogenic Ha-Ras-induced signaling activates NF-kappaB transcriptional activity, which is required for cellular transformation

1 reference

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7 January 2021

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

New insights into the role of nuclear factor-kB in cell growth regulation

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7 January 2021

Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB.

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7 January 2021

Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells

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7 January 2021

The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers

1 reference

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7 January 2021

Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Tumour necrosis factor and cancer

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Coley's toxins, tumor necrosis factor and cancer research: a historical perspective

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7 January 2021

An endotoxin-induced serum factor that causes necrosis of tumors

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7 January 2021

Inhibition of NF-kappaB sensitizes non-small cell lung cancer cells to chemotherapy-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Role of NF-κB in p53-mediated programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

NF-κB-mediated Induction ofmdr1bExpression by Insulin in Rat Hepatoma Cells

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Induction of Mdr1b expression by tumor necrosis factor-alpha in rat liver cells is independent of p53 but requires NF-kappaB signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Mechanisms of resistance to imatinib (STI571) and prospects for combination with conventional chemotherapeutic agents

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7 January 2021

New-age drug meets resistance

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The role of cytokines in cancer cachexia

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Intratumoral injection of oligonucleotides to the NF kappa B binding site inhibits cachexia in a mouse tumor model

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The TRAIL to an anti-cancer agent.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The use of TNF family ligands and receptors and agents which modify their interaction as therapeutic agents

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7 January 2021

The potential of TRAIL for cancer chemotherapy

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production by the introduction of a super-repressor form of inhibitor of nuclear factor kappaBalpha complementary DNA into immortalized human salivary gland acinar cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

1 reference

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7 January 2021

Activation of nuclear factor kappaB and Bcl-x survival gene expression by nerve growth factor requires tyrosine phosphorylation of IkappaBalpha.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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7 January 2021

Structure of GSK3beta reveals a primed phosphorylation mechanism

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7 January 2021

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation

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7 January 2021

The renaissance of GSK3

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https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

1 reference

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7 January 2021

Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibition of IkappaB kinase activity by sodium salicylate in vitro does not reflect its inhibitory mechanism in intact cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Sulindac inhibits activation of the NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Thalidomide: a novel template for anticancer drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

IkappaB kinases alpha and beta show a random sequential kinetic mechanism and are inhibited by staurosporine and quercetin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Proteasome regulation of activation-induced T cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The secondary fungal metabolite gliotoxin targets proteolytic activities of the proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Inhibition of farnesyl-protein transferase by gliotoxin and acetylgliotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Diverse agents act at multiple levels to inhibit the Rel/NF-kappaB signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

NF-kappa B as a therapeutic target in multiple myeloma

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2802%2902309-7

7 January 2021

10.1016/S1359-6446(02)02309-7

Identifiers

DOI

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4 August 2017

1 reference

PubMed ID

12110242