Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing (Q35541632)

8 August 2017

Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing (English)

1 reference

8 August 2017

1 reference

Shinsuke Araki

1

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author name string

Ryo Dairiki

2

1 reference

8 August 2017

Yusuke Nakayama

3

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8 August 2017

Aiko Murai

4

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8 August 2017

Risa Miyashita

5

1 reference

8 August 2017

Misa Iwatani

6

1 reference

8 August 2017

Toshiyuki Nomura

7

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8 August 2017

Osamu Nakanishi

8

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8 August 2017

language of work or name

English

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publication date

12 January 2015

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8 August 2017

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8 August 2017

10

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8 August 2017

1

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8 August 2017

e0116929

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Creative Commons Attribution 4.0 International

8 August 2017

start time

12 January 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus

27 July 2018

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WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing

27 July 2018

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Chemical treatment enhances skipping of a mutated exon in the dystrophin gene

27 July 2018

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Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A

27 July 2018

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The anti-tumor drug E7107 reveals an essential role for SF3b in remodeling U2 snRNP to expose the branch point-binding region

27 July 2018

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Arginine methylation controls the subcellular localization and functions of the oncoprotein splicing factor SF2/ASF

27 July 2018

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Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication.

27 July 2018

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Molecular mechanisms of mTOR-mediated translational control

27 July 2018

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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

27 July 2018

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The spliceosome: design principles of a dynamic RNP machine

27 July 2018

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The SR protein family of splicing factors: master regulators of gene expression

27 July 2018

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Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

27 July 2018

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The gene encoding the splicing factor SF2/ASF is a proto-oncogene

27 July 2018

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The connection between splicing and cancer.

27 July 2018

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Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma

27 July 2018

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The spliceosome: a novel multi-faceted target for therapy

27 July 2018

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Understanding alternative splicing: towards a cellular code

27 July 2018

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Manipulation of alternative splicing by a newly developed inhibitor of Clks

27 July 2018

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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays

27 July 2018

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Differential effects of hyperphosphorylation on splicing factor SRp55

27 July 2018

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Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

27 July 2018

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The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation

27 July 2018

1 reference

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The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

27 July 2018

1 reference

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Identification and characterization of a sphere organelle protein

27 July 2018

1 reference

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Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing

27 July 2018

1 reference

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TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

27 July 2018

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The development and application of small molecule modulators of SF3b as therapeutic agents for cancer.

26 September 2018

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The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

26 September 2018

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PARP inhibitors in breast cancer: BRCA and beyond.

26 September 2018

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Shuttling SR proteins: more than splicing factors

26 September 2018

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Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

26 September 2018

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Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones

26 September 2018

1 reference

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The emerging role of splicing factors in cancer

26 September 2018

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Splicing factor SF3b as a target of the antitumor natural product pladienolide.

26 September 2018

1 reference

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Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4291223

Serine-arginine protein kinase 1 overexpression is associated with tumorigenic imbalance in mitogen-activated protein kinase pathways in breast, colonic, and pancreatic carcinomas

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25581376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25581376

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0116929

1 reference

8 August 2017

0 references

1 reference

8 August 2017

1 reference