Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. (Q35423634)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25878277%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25878277%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

main subject

spinal muscular atrophy

1 reference

Survival of motor neuron 1, telomeric

inferred from title

1 reference

GOA release 2020-03-11

1 reference

1

1 reference

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5 March 2020

Jorge A Cantu

9

1 reference

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5 March 2020

Jacek Topczewski

10

1 reference

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5 March 2020

Charlotte Sumner

13

1 reference

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5 March 2020

Yong-Chao Ma

15

1 reference

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5 March 2020

author name string

Zhihua Feng

2

1 reference

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5 March 2020

Brittany M Edens

3

1 reference

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5 March 2020

Ben Yang

4

1 reference

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5 March 2020

Han Shi

5

1 reference

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5 March 2020

Christie C Sze

6

1 reference

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5 March 2020

Benjamin Taige Hong

7

1 reference

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5 March 2020

Susan C Su

8

1 reference

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5 March 2020

Thomas O Crawford

11

1 reference

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5 March 2020

Chien-Ping Ko

12

1 reference

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5 March 2020

Long Ma

14

1 reference

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5 March 2020

language of work or name

English

0 references

publication date

1 April 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25878277%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

published in

Journal of Neuroscience

1 reference

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5 March 2020

volume

35

1 reference

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5 March 2020

issue

15

1 reference

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5 March 2020

page(s)

6038-6050

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LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

5 March 2020

cites work

1 reference

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Improvement of neuromuscular synaptic phenotypes without enhanced survival and motor function in severe spinal muscular atrophy mice selectively rescued in motor neurons

27 July 2018

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Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies

27 July 2018

1 reference

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Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy

27 July 2018

1 reference

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Cyclin-dependent kinases in brain development and disease

27 July 2018

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27 July 2018

The many faces of tau

1 reference

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Cdk5-mediated phosphorylation of endophilin B1 is required for induced autophagy in models of Parkinson's disease

27 July 2018

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Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy

27 July 2018

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Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration

27 July 2018

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Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy

27 July 2018

1 reference

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Monte carlo simulations of tau proteins: effect of phosphorylation

27 July 2018

1 reference

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Cardiac defects contribute to the pathology of spinal muscular atrophy models

27 July 2018

1 reference

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Arrhythmia and cardiac defects are a feature of spinal muscular atrophy model mice

27 July 2018

1 reference

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Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models

27 July 2018

1 reference

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Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery

27 July 2018

1 reference

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Caspase activation precedes and leads to tangles

27 July 2018

1 reference

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Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?

27 July 2018

1 reference

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Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice

27 July 2018

1 reference

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Congenital heart disease is a feature of severe infantile spinal muscular atrophy

27 July 2018

1 reference

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Embryonic motor axon development in the severe SMA mouse

27 July 2018

1 reference

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Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy

27 July 2018

1 reference

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Phosphorylation regulates tau interactions with Src homology 3 domains of phosphatidylinositol 3-kinase, phospholipase Cgamma1, Grb2, and Src family kinases

27 July 2018

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Differential regulation of dynein and kinesin motor proteins by tau

27 July 2018

1 reference

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

27 July 2018

1 reference

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Tau protein, the paired helical filament and Alzheimer's disease

27 July 2018

1 reference

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Spinal muscular atrophy: a deficiency in a ubiquitous protein; a motor neuron-specific disease

27 July 2018

1 reference

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Tau suppression in a neurodegenerative mouse model improves memory function

27 July 2018

1 reference

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Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons

27 July 2018

1 reference

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Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding.

27 July 2018

1 reference

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Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau

27 July 2018

1 reference

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Neurodegenerative tauopathies

27 July 2018

1 reference

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Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions

27 July 2018

1 reference

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Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

27 July 2018

1 reference

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Neurotoxicity induces cleavage of p35 to p25 by calpain

27 July 2018

1 reference

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A mouse model for spinal muscular atrophy

27 July 2018

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

27 July 2018

1 reference

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A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

27 July 2018

1 reference

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Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

Tau interacts with src-family non-receptor tyrosine kinases

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

Characterization of tau phosphorylation in glycogen synthase kinase-3beta and cyclin dependent kinase-5 activator (p23) transfected cells

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

27 July 2018

1 reference

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Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

27 July 2018

1 reference

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Altered microtubule organization in small-calibre axons of mice lacking tau protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

Identification and characterization of a spinal muscular atrophy-determining gene

27 July 2018

1 reference

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Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

27 July 2018

1 reference

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

27 July 2018

1 reference

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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

27 July 2018

1 reference

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Distribution of tau proteins in the normal human central and peripheral nervous system

27 July 2018

1 reference

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Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

27 July 2018

1 reference

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One of the antigenic determinants of paired helical filaments is related to tau protein.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

Inhibition of neurite polarity by tau antisense oligonucleotides in primary cerebellar neurons

27 July 2018

1 reference

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A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

27 July 2018

1 reference

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Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons

27 July 2018

1 reference

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Tubulin requires tau for growth onto microtubule initiating sites

27 July 2018

1 reference

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A protein factor essential for microtubule assembly

27 July 2018

1 reference

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Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression.

27 July 2018

1 reference

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Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits.

26 September 2018

1 reference

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Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein.

26 September 2018

1 reference

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Conformational changes specific for pseudophosphorylation at serine 262 selectively impair binding of tau to microtubules

26 September 2018

1 reference

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Tau--an inhibitor of deacetylase HDAC6 function.

26 September 2018

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26 September 2018

Spinal muscular atrophy.

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Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK

26 September 2018

1 reference

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Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein.

26 September 2018

1 reference

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Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport

26 September 2018

1 reference

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Neural cell fate analysis in zebrafish using olig2 BAC transgenics.

26 September 2018

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Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.

26 September 2018

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Src tyrosine kinase is a novel direct effector of G proteins.

26 September 2018

1 reference

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Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice.

26 September 2018

1 reference

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Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

26 September 2018

1 reference

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Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex.

26 September 2018

1 reference

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A spatial gradient of tau protein phosphorylation in nascent axons.

26 September 2018

1 reference

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Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

26 September 2018

1 reference

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Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

26 September 2018

1 reference

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A brain-specific activator of cyclin-dependent kinase 5.

26 September 2018

1 reference

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Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

The carboxyl third of tau is tightly bound to paired helical filaments.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4397602

Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25878277

12 December 2020

inferred from PubMed ID database lookup

Neurofilament accumulation at the motor endplate and lack of axonal sprouting in a spinal muscular atrophy mouse model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25878277

12 December 2020

inferred from PubMed ID database lookup

SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25878277

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1523/JNEUROSCI.3716-14.2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25878277%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25878277%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference