Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins (Q34405465)

2 August 2017

title

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins (English)

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2 August 2017

P M Ayton

1

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2 August 2017

M L Cleary

series ordinal

2

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2 August 2017

publication date

1 September 2001

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2 August 2017

language of work or name

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2 August 2017

volume

20

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2 August 2017

issue

40

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2 August 2017

page(s)

5695-5707

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publication type of scholarly work

2 August 2017

review article

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The Drosophila homolog of human AF10/AF17 leukemia fusion genes (Dalf) encodes a zinc finger/leucine zipper nuclear protein required in the nervous system for maintaining EVE expression and normal growth

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E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

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The CBP co-activator is a histone acetyltransferase

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The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q

21 January 2018

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The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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TFG/TAF30/ANC1, a component of the yeast SWI/SNF complex that is similar to the leukemogenic proteins ENL and AF-9.

21 January 2018

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The amino terminus of the mixed lineage leukemia protein (MLL) promotes cell cycle arrest and monocytic differentiation

21 January 2018

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Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

21 January 2018

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Oncogenic conversion of transcription factors by chromosomal translocations

21 January 2018

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An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes

21 January 2018

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A component of the transcriptional repressor MeCP1 shares a motif with DNA methyltransferase and HRX proteins

21 January 2018

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Structure and ligand of a histone acetyltransferase bromodomain

21 January 2018

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The mll-AF9 gene fusion in mice controls myeloproliferation and specifies acute myeloid leukaemogenesis

21 January 2018

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Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene.

21 January 2018

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Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

21 January 2018

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The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family

21 January 2018

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Identification of the gene FMR2, associated with FRAXE mental retardation

21 January 2018

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Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island

21 January 2018

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AF15q14, a novel partner gene fused to the MLL gene in an acute myeloid leukaemia with a t(11;15)(q23;q14)

21 January 2018

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Two critical hits for promyelocytic leukemia

21 January 2018

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Identification and characterization of a family of mammalian methyl-CpG binding proteins

21 January 2018

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The solution structure of an HMG-I(Y)–DNA complex defines a new architectural minor groove binding motif

21 January 2018

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Hematologic malignancies with t(4;11)(q21;q23)--a cytogenetic, morphologic, immunophenotypic and clinical study of 183 cases. European 11q23 Workshop participants

21 January 2018

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Direct control of the Forkhead transcription factor AFX by protein kinase B

21 January 2018

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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

21 January 2018

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Identification of AF-6 and canoe as putative targets for Ras.

21 January 2018

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Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL

21 January 2018

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21 January 2018

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Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

21 January 2018

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RAS mutations in pediatric leukemias withMLL gene rearrangements

21 January 2018

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The acetyltransferase activity of CBP stimulates transcription

21 January 2018

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

21 January 2018

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Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors

21 January 2018

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Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3

21 January 2018

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canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila

21 January 2018

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The FEL (AF-4) protein donates transcriptional activation sequences to Hrx-Fel fusion proteins in leukemias containing T(4;11)(Q21;Q23) chromosomal translocations

21 January 2018

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Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.

21 January 2018

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Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs

21 January 2018

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Exon/intron structure of the human AF‐4 gene, a member of the AF‐4/LAF‐4/FMR‐2 gene family coding for a nuclear protein with structural alterations in acute leukaemia

21 January 2018

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

21 January 2018

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AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

21 January 2018

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Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP

21 January 2018

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Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia

21 January 2018

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Chromosomal translocations in human cancer.

21 January 2018

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Phosphorylation of the DNA-binding domain of nonhistone high-mobility group I protein by cdc2 kinase: reduction of binding affinity

21 January 2018

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The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex

21 January 2018

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ALL-1 partial duplication in acute leukemia

21 January 2018

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Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppresses v-abl transforming activity

21 January 2018

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An RNA polymerase II elongation factor encoded by the human ELL gene

21 January 2018

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ELL2, a new member of an ELL family of RNA polymerase II elongation factors

21 January 2018

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Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

The Oncogenic Capacity of HRX-ENL Requires the Transcriptional Transactivation Activity of ENL and the DNA Binding Motifs of HRX

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

ML-1 cell line lacks a germline MLL locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

An early haematopoietic defect in mice lacking the transcription factor GATA-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

Altered Hox expression and segmental identity in Mll-mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

MLL, a mammalian trithorax- group gene, functions as a transcriptional maintenance factor in morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

The Gcn5 bromodomain co-ordinates nucleosome remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

The der(11) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

inferred from DOI database lookup

7 January 2021

based on heuristic

General Report on the European Union Concerted Action Workshop on 11q23, London, UK, May 1997

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204639

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1204639

1 reference

Dimensions Publication ID

2 August 2017

1030340246

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