Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis (Q35195305)

7 August 2017

Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis (English)

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7 August 2017

Shuangwei Li

1

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7 August 2017

Diane D F Hsu

2

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7 August 2017

Bing Li

3

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7 August 2017

Xiaolin Luo

4

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7 August 2017

Nazilla Alderson

5

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7 August 2017

Liping Qiao

6

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7 August 2017

Lina Ma

7

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7 August 2017

Helen H Zhu

8

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7 August 2017

Zhao He

9

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7 August 2017

Kelly Suino-Powell

10

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7 August 2017

Kaihong Ji

11

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7 August 2017

Jiefu Li

12

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7 August 2017

Jianhua Shao

13

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7 August 2017

H Eric Xu

14

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7 August 2017

Tiangang Li

15

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7 August 2017

Gen-Sheng Feng

16

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7 August 2017

26 June 2014

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7 August 2017

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7 August 2017

20

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7 August 2017

2

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7 August 2017

320-332

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describes a project that uses

7 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4365973/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes

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Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels

13 July 2018

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Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

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Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

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FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway

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Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis

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Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

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Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

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Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

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Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis

13 July 2018

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A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice

13 July 2018

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13 July 2018

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FGF-receptor substrate 2 functions as a molecular sensor integrating external regulatory signals into the FGF pathway

13 July 2018

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Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

13 July 2018

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Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity

13 July 2018

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Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

13 July 2018

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The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis

13 July 2018

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PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase

13 July 2018

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Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection

13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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13 July 2018

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Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis

13 July 2018

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13 July 2018

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Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4

13 July 2018

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

13 July 2018

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Bile acids: natural ligands for an orphan nuclear receptor

13 July 2018

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Identification of a nuclear receptor for bile acids

13 July 2018

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The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases

13 July 2018

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Intestinal FXR-mediated FGF15 production contributes to diurnal control of hepatic bile acid synthesis in mice

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4365973

Bile acids have the gall to function as hormones

27 September 2018

1 reference

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Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation

27 September 2018

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Characterization of time-related changes after experimental bile duct ligation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4365973

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.

27 September 2018

1 reference

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Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

27 September 2018

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knocking down liver ccaat/enhancer-binding protein alpha by adenovirus-transduced silent interfering ribonucleic acid improves hepatic gluconeogenesis and lipid homeostasis in db/db mice.

27 September 2018

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Mild hepatic fibrosis in cholesterol and sodium cholate diet-fed rats

27 September 2018

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Resistance of SHP-null mice to bile acid-induced liver damage

27 September 2018

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4365973

Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation.

27 September 2018

1 reference

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Localization of Bile Salt Absorption In Vivo in the Rabbit

27 September 2018

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Characterizing Bile Acid and Lipid Metabolism in the Liver and Gastrointestinal Tract of Mice

27 September 2018

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12 December 2020

Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis

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12 December 2020

Bile salt absorption at various levels of rat small intenstine

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12 December 2020

Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration

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12 December 2020

10.1016/J.CMET.2014.05.020

Identifiers

DOI

1 reference

7 August 2017

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7 August 2017

1 reference