Genetic alterations in cancer as a result of breakage at fragile sites (Q35085395)

6 August 2017

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title

Genetic alterations in cancer as a result of breakage at fragile sites (English)

1 reference

6 August 2017

Nicholas C Popescu

1

1 reference

PubMed ID

12637148

6 August 2017

language of work or name

English

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publication date

1 March 2003

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6 August 2017

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6 August 2017

192

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6 August 2017

1-17

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6 August 2017

1

1 reference

Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes

6 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Fragile sites still breaking

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

FRA3B and other common fragile sites: the weakest links

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Fragile and unstable chromosomes in cancer: causes and consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosomal fragile sites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Fragile sites, cancer chromosome breakpoints, and oncogenes all cluster in light G bands.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

A view of interphase chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The enigma of common fragile sites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Trinucleotide repeat amplification and hypermethylation of a CpG island in FRAXE mental retardation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Isolation of a GCC repeat showing expansion in FRAXF, a fragile site distal to FRAXA and FRAXE

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Implications of FRA16A structure for the mechanism of chromosomal fragile site genesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Physical linkage of the fragile site FRA11B and a Jacobsen syndrome chromosome deletion breakpoint in 11q23.3.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Sister Chromatid Exchange and Chromosome Aberration Analysis With the Use of Several Carcinogens and Noncarcinogens: Brief Communication

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosome fragility and instability in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Sister chromatid exchanges are preferentially induced at expressed and nonexpressed common fragile sites

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

"Spontaneous" FRA16B is a hot spot for sister chromatid exchanges

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Induction of distamycin A-inducible rare fragile sites and increased sister chromatid exchanges at the fragile site

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The molecular genetics of cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

A breakpoint map of recurrent chromosomal rearrangements in human neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Constitutive fragile sites and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Onco gen: Human oncogene locations and chromosome aberrations

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosomal fragile sites and cancer-specific breakpoints--a moderating viewpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Familial fragile 8q22 involved as a cancer breakpoint in cells of a large bowel tumor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosomal translocations in human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Novel genomic imbalances and chromosome translocations involving c-myc gene in Burkitt's lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Recombination and amplification of pyrimidine-rich sequences may be responsible for initiation and progression of the Xq27 fragile site: an hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Proximity of chromosomal loci that participate in radiation-induced rearrangements in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The clinical significance of fragile sites on human chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Nonrandom breakpoints of unbalanced chromosome translocations in human hepatocellular carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Antioncogenes and human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The fundamental role of epigenetic events in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Metaphase chromosome anomaly: association with drug resistance and cell-specific products

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Oncogene amplification in tumor cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Dynamic instability of chromosomes and genomes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosome organization and genic expression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Comparative genomic hybridisation for the analysis of chromosomal imbalances in solid tumours and haematological malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The involvement of the chromosome 11q13 region in human malignancies: cyclin D1 and EMS1 are two new candidate oncogenes--a review

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

A consistent pattern ofRIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage-fusion-bridge cycle model for 11q13 amplification

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

A role for common fragile site induction in amplification of human oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

DNA amplification associated with double minutes originating from chromosome 19 in mouse hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Rodent common fragile sites: are they conserved? Evidence from mouse and rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Restoration of fragile histidine triad (FHIT) expression induces apoptosis and suppresses tumorigenicity in lung and cervical cancer cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Muir-Torre-like syndrome in Fhit-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

How can we prevent cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

BRCA2: a genetic risk factor for breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosome imbalance at the 3p14 region in human breast tumours: high frequency in patients with inherited predisposition due to BRCA2.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Nuclear enzymes, fragile sites, and cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23)

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Direct correlation between FRA3B expression and cigarette smoking

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Transcriptional profiling reveals that several common fragile-site genes are downregulated in ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Integrated genomes of animal viruses

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Integration of Oncogenic Viruses in Mammalian Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Human papillomavirus-negative status and c-myc gene overexpression: independent prognostic indicators of distant metastasis for early-stage invasive cervical cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Herpes simplex virus and human papillomavirus sites correlate with chromosomal breakpoints in human cervical carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosome fragility in lymphocytes of women with cervical uterine lesions produced by human papillomavirus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Preferential sites for viral integration on mammalian genome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosomal organization of viral integration sites in human papillomavirus-immortalized human keratinocyte cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Integration site of human papillomavirus type-18 DNA in chromosome band 8q22.1 of C4-I cervical carcinoma: DNase I hypersensitivity and methylation of cellular flanking sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

APM-1, a novel human gene, identified by aberrant co-transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ-zinc finger protein with growth inhibitory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Single copy heterozygote integration of HPV 33 in chromosomal band 5p14 is found in an epithelial cell clone with selective growth advantage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Simultaneous mapping of human papillomavirus integration sites and molecular karyotyping in short-term cultures of cervical carcinomas by using 49-color combined binary ratio labeling fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosomal assignment of woodchuck hepatitis virus (WHV) DNA integration sites in a woodchuck hepatocellular carcinoma-derived cell line (WH257GE10).

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosome-mediated alterations of the MYC gene in human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

cis-Activation of the human telomerase gene (hTERT) by the hepatitis B virus genome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Novel recurrent genetic imbalances in human hepatocellular carcinoma cell lines identified by comparative genomic hybridization

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

When Epstein-Barr virus persistently infects B-cell lines, it frequently integrates

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Sensitive, high-resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a lymphoma line

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

A Burkitt lymphoma cell line with integrated Epstein-Barr virus at a stable chromosome modification site

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Site-specific integration by adeno-associated virus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

Targeted integration of adeno-associated virus (AAV) into human chromosome 19

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2802%2900596-7

7 January 2021

10.1016/S0304-3835(02)00596-7

Identifiers

DOI

1 reference

6 August 2017

1 reference

PubMed ID

12637148