The role of Tec family kinases in T cell development and function (Q35076690)

6 August 2017

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title

The role of Tec family kinases in T cell development and function (English)

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6 August 2017

Julie A Lucas

1

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6 August 2017

Andrew T Miller

series ordinal

2

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6 August 2017

Luana O Atherly

series ordinal

3

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6 August 2017

Leslie J Berg

series ordinal

4

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6 August 2017

language of work or name

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1 February 2003

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6 August 2017

Immunological Reviews

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6 August 2017

191

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6 August 2017

119-138

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New insights into the regulation and functions of Tec family tyrosine kinases in the immune system

6 August 2017

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Interaction of SLP adaptors with the SH2 domain of Tec family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Involvement of LAT, Gads, and Grb2 in compartmentation of SLP-76 to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Tec family kinases modulate thresholds for thymocyte development and selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Profound block in thymocyte development in mice lacking p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Essential role for ZAP-70 in both positive and negative selection of thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

The absence of Itk inhibits positive selection without changing lineage commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

T cell receptor antagonist peptides induce positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

A role for the Tec family tyrosine kinase Txk in T cell activation and thymocyte selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

New perspectives on a developmental dilemma: the kinetic signaling model and the importance of signal duration for the CD4/CD8 lineage decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Survival of mature CD4 T lymphocytes is dependent on major histocompatibility complex class II-expressing dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Ca2+ signaling modulates cytolytic T lymphocyte effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Dendritic cells and immunity to leishmaniasis and toxoplasmosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Induction of T helper type 2 immunity by a point mutation in the LAT adaptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

A LAT mutation that inhibits T cell development yet induces lymphoproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Identification of the minimal tyrosine residues required for linker for activation of T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Regulation of the murine Nfatc1 gene by NFATc2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

JNK1 is required for T cell-mediated immunity against Leishmania major infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Signal transduction during natural killer cell activation: inside the mind of a killer

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Macromolecular protein signaling complexes and mast cell responses: a view of the organization of IgE-dependent mast cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Defective T Cell Differentiation in the Absence of Jnk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Self-recognition and the regulation of CD4+ T cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Mutation of Tec family kinases alters T helper cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

Tec kinases: a family with multiple roles in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Lck activity controls CD4/CD8 T cell lineage commitment.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Inducible Expression of a p56Lck Transgene Reveals a Central Role for Lck in the Differentiation of CD4 SP Thymocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

The influence of the MAPK pathway on T cell lineage commitment

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Antiviral immune responses in Itk-deficient mice.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

NFAT signaling: choreographing the social lives of cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

An enhanced immune response in mice lacking the transcription factor NFAT1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

Down-regulation of IL-4 gene transcription and control of Th2 cell differentiation by a mechanism involving NFAT1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

The transcription factor NFAT4 is involved in the generation and survival of T cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

NFATc1 and NFATc2 together control both T and B cell activation and differentiation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2003.00029.X

7 January 2021

10.1034/J.1600-065X.2003.00029.X

Identifiers

DOI

1 reference

6 August 2017

1 reference