Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1. (Q35048864)

6 August 2017

title

Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1. (English)

1 reference

6 August 2017

Vincent Lisowski

2

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Frédéric Checler

object named as

Frédéric Checler

5

0 references

Jean Martinez

object named as

Jean Martinez

4

0 references

Jean-François Hernandez

3

object named as

Jean-François Hernandez

1 reference

6 August 2017

author name string

Solveig Lefranc-Jullien

1

1 reference

6 August 2017

language of work or name

English

0 references

publication date

1 May 2005

1 reference

British Journal of Pharmacology

6 August 2017

published in

1 reference

6 August 2017

volume

145

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6 August 2017

issue

2

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6 August 2017

page(s)

228-235

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Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

6 August 2017

cites work

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Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

8 July 2018

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Beta-secretase activity increases with aging in human, monkey, and mouse brain.

8 July 2018

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Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase

8 July 2018

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Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR.

8 July 2018

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Human β-Secretase (BACE) and BACE Inhibitors

8 July 2018

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The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

8 July 2018

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BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

8 July 2018

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BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

8 July 2018

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Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase

8 July 2018

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Beta-secretase (BACE) as a drug target for Alzheimer's disease

8 July 2018

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8 July 2018

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Inhibition of BACE, a promising approach to Alzheimer's disease therapy

8 July 2018

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Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

8 July 2018

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

8 July 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

8 July 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

8 July 2018

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

8 July 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

8 July 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

8 July 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

8 July 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

8 July 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

8 July 2018

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Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

8 July 2018

1 reference

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Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid beta peptides: their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiop

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Skeletal and CNS defects in Presenilin-1-deficient mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Generation of beta A4 from the amyloid protein precursor and fragments thereof

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Alzheimer's disease: the amyloid cascade hypothesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Rational design and synthesis of selective BACE-1 inhibitors

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Design and synthesis of statine-containing BACE inhibitors

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta -secretase (BACE1).

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1576132

25 October 2018

Identifiers

DOI

10.1038/SJ.BJP.0706183

1 reference

6 August 2017

1 reference

6 August 2017

1 reference