Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. (Q48158450)

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10 December 2019

title

Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain (English)

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10 December 2019

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3

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10 December 2019

author name string

K Y Lee

1

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10 December 2019

A W Clark

2

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10 December 2019

K Chapman

4

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10 December 2019

T Fung

5

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10 December 2019

R N Johnston

6

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10 December 2019

publication date

1 May 1999

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10 December 2019

published in

Neuroscience Research

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10 December 2019

volume

34

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10 December 2019

issue

1

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10 December 2019

page(s)

21-29

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Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5

10 December 2019

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Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau.

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A family of human cdc2-related protein kinases

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Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex.

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Proline-directed and non-proline-directed phosphorylation of PHF-tau.

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Brain protein kinase PK40erk converts TAU into a PHF-like form as found in Alzheimer's disease.

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Identifiers

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10 December 2019

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