Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs (Q34816073)

4 August 2017

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title

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs (English)

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4 August 2017

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Jonathan B Baell

1

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PubMed ID

12213579

4 August 2017

David C S Huang

series ordinal

2

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PubMed ID

12213579

4 August 2017

language of work or name

English

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publication date

1 September 2002

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4 August 2017

Biochemical Pharmacology

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4 August 2017

64

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4 August 2017

5-6

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4 August 2017

851-863

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Apoptosis in the pathogenesis and treatment of disease

4 August 2017

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Involvement of the bcl-2 gene in human follicular lymphoma

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Cancer. p53, guardian of the genome

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

p53 is required for radiation-induced apoptosis in mouse thymocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Apoptosis in cancer therapy: crossing the threshold

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

7 January 2021

Caspases: enemies within

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Death receptors: signaling and modulation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

An antagonist decoy receptor and a death domain-containing receptor for TRAIL

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Life-or-death decisions by the Bcl-2 protein family.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L).

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Interaction and regulation of subcellular localization of CED-4 by CED-9

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

The Bcl-2 protein family: arbiters of cell survival

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

BH3-Only proteins-essential initiators of apoptotic cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

PUMA induces the rapid apoptosis of colorectal cancer cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

PUMA, a novel proapoptotic gene, is induced by p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Structure of Bax: coregulation of dimer formation and intracellular localization

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bax directly induces release of cytochrome c from isolated mitochondria

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

BID: a novel BH3 domain-only death agonist

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

bcl-x prevents apoptotic cell death of both primitive and definitive erythrocytes at the end of maturation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Testicular degeneration in Bclw-deficient mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Solution structure of the antiapoptotic protein bcl-2

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Miniaturized proteins: the backbone cyclic proteinomimetic approach

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

The mechanism of alpha-helix formation by peptides

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Design and Evolution of a Miniature Bcl-2 Binding Protein We thank the HHMI Biopolymer/Keck Foundation Biotechnology Resource Laboratory (Yale University School of Medicine, New Haven, CT) for oligonucleotide and peptide synthesis and amino acid ana

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Inhibition of HIV type 1 infectivity by constrained alpha-helical peptides: implications for the viral fusion mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Folding study of an Aib-rich peptide in DMSO by molecular dynamics simulations

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

The BH3 domain of BAD fused to the Antennapedia peptide induces apoptosis via its alpha helical structure and independent of Bcl-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Single-chain lipopeptide vaccines for the induction of virus-specific cytotoxic T cell responses in randomly selected populations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Molecular transporters for peptides: delivery of a cardioprotective epsilonPKC agonist peptide into cells and intact ischemic heart using a transport system, R(7).

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Peptide and Protein Recognition by Designed Molecules

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Antagonists of protein-protein interactions.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Protein-protein interfaces: mimics and inhibitors

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Scoring noncovalent protein-ligand interactions: a continuous differentiable function tuned to compute binding affinities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Design and synthesis of type-III mimetics of omega-conotoxin GVIA

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Mimicking dominant negative inhibition of prion replication through structure-based drug design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

The design of dipeptide helical mimetics: The synthesis, tachykinin receptor affinity and conformational analysis of 1,1,6-trisubstituted indanes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Design and biological evaluation of non-peptide analogues of omega-conotoxin MVIIA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

CAVEAT: a program to facilitate the design of organic molecules

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

Computer-Guided Design in Molecular Recognition: Design and Synthesis of a Glucopyranose Receptor This work was supported by the National Institutes of Health (grant DK5523402)

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

BCL-2 family members and the mitochondria in apoptosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-2952%2802%2901148-6

10.1016/S0006-2952(02)01148-6

7 January 2021

Identifiers

DOI

1 reference

4 August 2017

1 reference

PubMed ID

12213579