Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity. (Q34755985)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

review article

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title

Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Patrick Brown

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

publication date

1 December 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

published in

Hematological Oncology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

volume

27

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1 February 2020

page(s)

171-181

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1 February 2020

issue

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

HOX expression patterns identify a common signature for favorable AML.

1 February 2020

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Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma

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Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-kappaB in AML carrying NPM1 mutations

7 July 2018

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MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia

7 July 2018

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Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin

7 July 2018

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Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

7 July 2018

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Nucleophosmin/B23 negatively regulates GCN5-dependent histone acetylation and transactivation

7 July 2018

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Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53.

7 July 2018

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7 July 2018

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The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

7 July 2018

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MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

7 July 2018

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Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants

7 July 2018

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The incidence and clinical significance of nucleophosmin mutations in childhood AML.

7 July 2018

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Evaluation of recurring cytogenetic abnormalities in the treatment of myelodysplastic syndromes

7 July 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

7 July 2018

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MicroRNA expression and function in cancer

7 July 2018

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Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features

7 July 2018

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Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification

7 July 2018

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7 July 2018

Nucleophosmin and cancer

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Nucleophosmin is essential for ribosomal protein L5 nuclear export

7 July 2018

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Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

7 July 2018

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Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML).

7 July 2018

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

7 July 2018

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Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein

7 July 2018

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Nucleophosmin is required for DNA integrity and p19Arf protein stability

7 July 2018

1 reference

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Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

7 July 2018

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Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription

7 July 2018

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Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

7 July 2018

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

7 July 2018

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Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype

7 July 2018

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Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

7 July 2018

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Role of nucleophosmin in embryonic development and tumorigenesis

7 July 2018

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A proteomics approach for the identification of nucleophosmin and heterogeneous nuclear ribonucleoprotein C1/C2 as chromatin-binding proteins in response to DNA double-strand breaks

7 July 2018

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

7 July 2018

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ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

7 July 2018

1 reference

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N-terminal polyubiquitination and degradation of the Arf tumor suppressor

7 July 2018

1 reference

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Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

7 July 2018

1 reference

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MicroRNA-directed cleavage of HOXB8 mRNA

7 July 2018

1 reference

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Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23

7 July 2018

1 reference

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FLT3: ITDoes matter in leukemia

7 July 2018

1 reference

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Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing

7 July 2018

1 reference

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Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization

7 July 2018

1 reference

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The roles of FLT3 in hematopoiesis and leukemia

7 July 2018

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Nucleophosmin regulates the stability and transcriptional activity of p53

7 July 2018

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Nuclear transcription factor-kappaB as a target for cancer drug development

7 July 2018

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Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry

7 July 2018

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

7 July 2018

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7 July 2018

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Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

7 July 2018

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Nucleolar Arf sequesters Mdm2 and activates p53

7 July 2018

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Nucleolar protein B23 has molecular chaperone activities

7 July 2018

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GADD45 induction of a G2/M cell cycle checkpoint

7 July 2018

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The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties

7 July 2018

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Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

7 July 2018

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

7 July 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

7 July 2018

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Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

7 July 2018

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The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

7 July 2018

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The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion

7 July 2018

1 reference

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma

7 July 2018

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The ribonuclease activity of nucleolar protein B23.

7 July 2018

1 reference

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Major nucleolar proteins shuttle between nucleus and cytoplasm

7 July 2018

1 reference

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Structure of the gene for rat nucleolar protein B23.

7 July 2018

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Genes preferentially expressed in embryo stomach are predominantly expressed in gastric cancer

7 July 2018

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NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.

7 July 2018

1 reference

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In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML.

26 October 2018

1 reference

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Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD.

26 October 2018

1 reference

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Analysis of NPM1 gene mutations in Chinese adults with acute myeloid leukemia

26 October 2018

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Mutations and promoter methylation status of NPM1 in myeloproliferative disorders.

26 October 2018

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C-terminal nucleophosmin mutations are uncommon in chronic myeloid disorders.

26 October 2018

1 reference

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Quantitative assessment of minimal residual disease in acute myeloid leukemia carrying nucleophosmin (NPM1) gene mutations.

26 October 2018

1 reference

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Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.

26 October 2018

1 reference

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B23/nucleophosmin serine 4 phosphorylation mediates mitotic functions of polo-like kinase 1.

26 October 2018

1 reference

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Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML.

26 October 2018

1 reference

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Expression of nucleophosmin/B23 in normal and neoplastic colorectal mucosa.

26 October 2018

1 reference

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Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

26 October 2018

1 reference

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A new type of NPM1 gene mutation in AML leading to a C-terminal truncated protein

9 December 2018

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12 December 2020

Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomas

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12 December 2020

Absence of nucleophosmin leukaemic mutants in B and T cells from AML with NPM1 mutations: implications for the cell of origin of NPMc+ AML

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12 December 2020

Induction of immune responses to ovarian tumor antigens by multiparity

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12 December 2020

Hematologic malignancies

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12 December 2020

Nek2A kinase regulates the localization of numatrin to centrosome in mitosis

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12 December 2020

Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities

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12 December 2020

The nucleic acid binding activity of nucleolar protein B23.1 resides in its carboxyl-terminal end

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12 December 2020

ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age

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12 December 2020

Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA)

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12 December 2020

Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML

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12 December 2020

Monoclonal antibody to prostate cancer nuclear matrix protein (PRO:4-216) recognizes nucleophosmin/B23

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12 December 2020

B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest

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12 December 2020

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

1 reference

12 December 2020

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

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12 December 2020

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia

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12 December 2020

Nucleophosmin mutations in de novo acute myeloid leukemia: the age-dependent incidences and the stability during disease evolution

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12 December 2020

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

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12 December 2020

NPM1 mutations in myelodysplastic syndromes and acute myeloid leukemia with normal karyotype

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12 December 2020

Different types of NPM1 mutations in children and adults: evidence for an effect of patient age on the prevalence of the TCTG-tandem duplication in NPM1-exon 12

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12 December 2020

Identification and functional characterization of a cytoplasmic nucleophosmin leukaemic mutant generated by a novel exon-11 NPM1 mutation

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12 December 2020

Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations

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12 December 2020

Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers

1 reference

12 December 2020

No nucleophosmin mutations in pediatric acute myeloid leukemia with normal karyotype: a study of the Japanese Childhood AML Cooperative Study Group

1 reference

12 December 2020

EXPRESSION OF NUCLEOPHOSMIN/B23 IN NORMAL AND NEOPLASTIC COLORECTAL MUCOSA

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FHON.904

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/HON.904

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19569254%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference