Perforin: structure, function, and role in human immunopathology (Q34620426)

3 August 2017

1 reference

title

Perforin: structure, function, and role in human immunopathology (English)

1 reference

3 August 2017

Joseph A Trapani

5

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James C Whisstock

object named as

James C Whisstock

4

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author name string

Ilia Voskoboinik

1

1 reference

PubMed ID

20536554

3 August 2017

Michelle A Dunstone

2

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PubMed ID

20536554

3 August 2017

Katherine Baran

3

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3 August 2017

1 May 2010

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3 August 2017

Immunological Reviews

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3 August 2017

235

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3 August 2017

1

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3 August 2017

35-54

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

3 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Ultrastructural alteration of cytolytic T lymphocytes following their interaction with target cells. II. Morphogenesis of secretory granules and intracellular vacuoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Endolysosomal proteases and their inhibitors in immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Secretory mechanisms in cell-mediated cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A Proteomic Analysis of Lysosomal Integral Membrane Proteins Reveals the Diverse Composition of the Organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Synergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Homology of perforin to the ninth component of complement (C9).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Structure and function of human perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

In vitro- and ex vivo-derived cytolytic leukocytes from granzyme A x B double knockout mice are defective in granule-mediated apoptosis but not lysis of target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Decreased tumor surveillance in perforin-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A critical analysis of the tumour immunosurveillance controversy for 3-MCA-induced sarcomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Host perforin reduces tumor number but does not increase survival in oncogene-driven mammary adenocarcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Aids-related malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cancer immunoediting: from immunosurveillance to tumor escape

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Occurrence of malignancy in immunodeficiency diseases. A literature review

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The role of tumor stroma in the interaction between tumor and immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin-mediated target-cell death and immune homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Localization of a gene for familial hemophagocytic lymphohistiocytosis at chromosome 9q21.3-22 by homozygosity mapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Familial and acquired hemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis due to perforin mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A noncytotoxic mast cell tumor line exhibits potent IgE-dependent cytotoxicity after transfection with the cytolysin/perforin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The global distribution of clinical episodes of Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Acquired immunity and postnatal clinical protection in childhood cerebral malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin mediated apoptosis of cerebral microvascular endothelial cells during experimental cerebral malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin-dependent brain-infiltrating cytotoxic CD8+ T lymphocytes mediate experimental cerebral malaria pathogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Hyperbaric oxygen prevents early death caused by experimental cerebral malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Development of insulitis without diabetes in transgenic mice lacking perforin-dependent cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

CD8+ T cells in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The major human and mouse granzymes are structurally and functionally divergent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile rheumatoid arthritis and macrophage activation syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Mutations of the hemophagocytic lymphohistiocytosis-associated gene UNC13D in a patient with systemic juvenile idiopathic arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Coxsackievirus B3-induced myocarditis: perforin exacerbates disease, but plays no detectable role in virus clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Anti-perforin neutralizing antibody reduces myocardial injury in viral myocarditis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cell-mediated cytotoxicity in hearts with dilated cardiomyopathy: correlation with interstitial fibrosis and foci of activated T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

NS1 specific CD8+ T-cells with effector function and TRBV11 dominance in a patient with parvovirus B19 associated inflammatory cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cytotoxic cell granule-mediated apoptosis. Characterization of the macromolecular complex of granzyme B with serglycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Perforin triggers a plasma membrane-repair response that facilitates CTL induction of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Cytolytic T cell granules. Isolation, structural, biochemical, and functional characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The ninth component of complement and the pore-forming protein (perforin 1) from cytotoxic T cells: structural, immunological, and functional similarities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

How far divergent evolution goes in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Mutations in the putative lipid-interaction domain of complement C9 result in defective secretion of the functional protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A common fold mediates vertebrate defense and bacterial attack

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Structural basis of pore formation by the bacterial toxin pneumolysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The Mechanism of Membrane Insertion for a Cholesterol-Dependent Cytolysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Identification of a Membrane-Spanning Domain of the Thiol-Activated Pore-Forming ToxinClostridium perfringensPerfringolysin O: An α-Helical to β-Sheet Transition Identified by Fluorescence Spectroscopy†

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Vertical collapse of a cytolysin prepore moves its transmembrane beta-hairpins to the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The domains of a cholesterol-dependent cytolysin undergo a major FRET-detected rearrangement during pore formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The MACPF/CDC family of pore-forming toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

MUSTANG: a multiple structural alignment algorithm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

The molecular basis for perforin oligomerization and transmembrane pore assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Six novel mutations in the PRF1 gene in children with haemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Functional consequences of perforin gene mutations in 22 patients with familial haemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Autoimmune Lymphoproliferative Syndrome and Perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Clinical and molecular aspects of Turkish familial hemophagocytic lymphohistiocytosis patients with perforin mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Development of hemophagocytic lymphohistiocytosis in triplets infected with HHV-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Severe and progressive encephalitis as a presenting manifestation of a novel missense perforin mutation and impaired cytolytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A proportion of patients with lymphoma may harbor mutations of the perforin gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A teenage boy with late onset hemophagocytic lymphohistiocytosis with predominant neurologic disease and perforin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Atypical features of familial hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Chronic active Epstein-Barr virus infection associated with mutations in perforin that impair its maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

Novel perforin mutation in a patient with hemophagocytic lymphohistiocytosis and CD45 abnormal splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2010.00896.X

10.1111/J.0105-2896.2010.00896.X

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

20536554