Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice (Q28594763)

31 January 2017

title

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice (English)

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Perforin 1 (pore forming protein)

31 January 2017

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GOA release 2020-03-11

8

R. M. Zinkernagel

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31 January 2017

D. Kägi

1

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31 January 2017

B. Ledermann

2

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31 January 2017

K. Bürki

3

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31 January 2017

P. Seiler

4

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31 January 2017

B. Odermatt

5

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31 January 2017

K. J. Olsen

6

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31 January 2017

E. R. Podack

7

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31 January 2017

H. Hengartner

9

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31 January 2017

publication date

5 May 1994

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31 January 2017

language of work or name

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31 January 2017

volume

369

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31 January 2017

issue

6475

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31 January 2017

page(s)

31–37

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Recovery from acute virus infection. Role of cytotoxic T lymphocytes in the elimination of lymphocytic choriomeningitis virus from spleens of mice

31 January 2017

cites work

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7 January 2021

CTL: virus control cells first and cytolytic cells second? DNA fragmentation, apoptosis and the prelytic halt hypothesis

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7 January 2021

Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo

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7 January 2021

Internal Disintegration Model of Cytotoxic Lymphocyte-Induced Target Damage

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7 January 2021

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

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7 January 2021

Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation

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7 January 2021

Cytolysis by H-2-specific T killer cells. Assembly of tubular complexes on target membranes

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7 January 2021

Purification and characterization of a cytolytic pore-forming protein from granules of cloned lymphocytes with natural killer activity

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7 January 2021

Mechanism of lymphocyte-mediated cytotoxicity

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7 January 2021

Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell granules

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7 January 2021

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

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7 January 2021

Structure and function of human perforin

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7 January 2021

Homology of perforin to the ninth component of complement (C9).

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7 January 2021

Structure, function and expression of murine and human perforin 1 (P1).

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7 January 2021

Expression of perforin in murine natural killer cells and cytotoxic T lymphocytes in vivo

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7 January 2021

Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus

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7 January 2021

A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.

1 reference

7 January 2021

Perforin-mediated myocardial damage in acute myocarditis

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7 January 2021

Genomic organization of the mouse pore-forming protein (perforin) gene and localization to chromosome 10. Similarities to and differences from C9.

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7 January 2021

A central role of perforin in cytolysis?

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7 January 2021

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

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7 January 2021

Establishment of a germ-line competent C57BL/6 embryonic stem cell line

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7 January 2021

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

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7 January 2021

T cell-mediated hepatitis in mice infected with lymphocytic choriomeningitis virus. Liver cell destruction by H-2 class I-restricted virus-specific cytotoxic T cells as a physiological correlate of the 51Cr-release assay?

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7 January 2021

Virus-induced delayed-type hypersensitivity reaction is sequentially mediated by CD8+ and CD4+ T lymphocytes

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7 January 2021

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression

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7 January 2021

LCMV-specific, class II-restricted cytotoxic T cells in beta 2-microglobulin-deficient mice

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7 January 2021

Enhanced tumor susceptibility of immunocompetent mice infected with lymphocytic choriomeningitis virus

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7 January 2021

The molecular mechanism of lymphocyte-mediated tumor cell lysis

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7 January 2021

Distinct patterns of virus-specific T cell-mediated cytolysis of transformed versus primary target cells

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7 January 2021

Immune response in mice that lack the interferon-gamma receptor

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7 January 2021

Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates

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7 January 2021

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1 reference

7 January 2021

Expression of retroviral vectors in transgenic mice obtained by embryo infection

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7 January 2021

Structure of the mouse pore-forming protein (perforin) gene: analysis of transcription initiation site, 5' flanking sequence, and alternative splicing of 5' untranslated regions

1 reference

7 January 2021

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1 reference

7 January 2021