The major human and mouse granzymes are structurally and functionally divergent (Q24682724)

7

0 references

Phillip I. Bird

object named as

Phillip I Bird

9

0 references

Joseph A. Trapani

object named as

Joseph A Trapani

8

0 references

author name string

Dion Kaiserman

1

0 references

Catherina H Bird

2

0 references

Jiuru Sun

3

0 references

Antony Matthews

4

0 references

Kheng Ung

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

5

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language of work or name

English

0 references

publication date

20 November 2006

0 references

published in

Journal of Cell Biology

0 references

volume

175

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page(s)

619-30

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issue

4

0 references

cites work

1 reference

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The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity

7 April 2017

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The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

7 April 2017

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On the size of the active site in proteases. I. Papain

7 April 2017

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Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules

7 April 2017

1 reference

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The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

7 April 2017

1 reference

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Serpin structure, mechanism, and function

7 April 2017

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Neutrophil elastase targets virulence factors of enterobacteria

7 April 2017

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Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

7 April 2017

1 reference

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Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

7 April 2017

1 reference

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Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

7 April 2017

1 reference

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Characterization of structural determinants of granzyme B reveals potent mediators of extended substrate specificity

7 April 2017

1 reference

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A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

7 April 2017

1 reference

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Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

7 April 2017

1 reference

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Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells

28 September 2017

1 reference

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Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

28 September 2017

1 reference

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Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.

28 September 2017

1 reference

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Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis

28 September 2017

1 reference

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Granzyme N, a novel granzyme, is expressed in spermatocytes and spermatids of the mouse testis

28 September 2017

1 reference

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Nuclear war: the granzyme A-bomb

28 September 2017

1 reference

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Granzyme B: pro-apoptotic, antiviral and antitumor functions

28 September 2017

1 reference

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A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite

28 September 2017

1 reference

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Nonredundant role of Bax and Bak in Bid-mediated apoptosis

28 September 2017

1 reference

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Granzyme B-induced apoptosis requires both direct caspase activation and relief of caspase inhibition

28 September 2017

1 reference

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Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis

28 September 2017

1 reference

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Lymphocyte-mediated cytotoxicity.

28 September 2017

1 reference

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Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.

28 September 2017

1 reference

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Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O

28 September 2017

1 reference

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Expression and purification of recombinant human granzyme B from Pichia pastoris

28 September 2017

1 reference

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Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway

28 September 2017

1 reference

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Definition and redesign of the extended substrate specificity of granzyme B.

28 September 2017

1 reference

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A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

Bcl-2, Bcl-XL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

Long-range disruption of gene expression by a selectable marker cassette

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

A survey of furin substrate specificity using substrate phage display

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

Characterization of recombinant mouse perforin expressed in insect cells using the baculovirus system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2064598

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis

30 May 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

Granzyme B-mediated apoptosis proceeds predominantly through a Bcl-2-inhibitable mitochondrial pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

A central role for Bid in granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

Comparison of Human Chromosome 6p25 with Mouse Chromosome 13 Reveals a Greatly Expanded Ov-Serpin Gene Repertoire in the Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200606073

The contribution of the conserved hinge region residues of alpha1-antitrypsin to its reaction with elastase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17116752

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17116752

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200606073

1 reference

1817956

1817956

1 reference

1 reference

1 reference