A role for p53 in the frequency and mechanism of mutation (Q34572898)

3 August 2017

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title

A role for p53 in the frequency and mechanism of mutation (English)

1 reference

3 August 2017

Suzanne M Morris

1

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PubMed ID

11906841

3 August 2017

language of work or name

English

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publication date

1 March 2002

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3 August 2017

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3 August 2017

511

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3 August 2017

1

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3 August 2017

45-62

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Cancer. p53, guardian of the genome

3 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Covalent and noncovalent modifiers of the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

How phosphorylation regulates the activity of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 Phosphorylation: biochemical and functional consequences

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

New developments in the multi-site phosphorylation and integration of stress signalling at p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Maintenance of genomic integrity by p53: complementary roles for activated and non-activated p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Regulation of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 regulation by post-translational modification and nuclear retention in response to diverse stresses

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

SUMO-1 modification activates the transcriptional response of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Evolutionary conservation and somatic mutation hotspot maps of p53: correlation with p53 protein structural and functional features.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 mutational spectra and the role of methylated CpG sequences

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 tumor-suppressor gene: clues to molecular carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Dissociation of the recombination control and the sequence-specific transactivation function of P53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The dual role model for p53 in maintaining genomic integrity

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Cell cycle traverse in AHH-1 tk +/- human lymphoblastoid cells exposed to the chromosomal mutagen, m-amsa

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 regulates a G2 checkpoint through cyclin B1

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Inhibition of RNA polymerase II as a trigger for the p53 response

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Direct influence of the p53 tumor suppressor on mitochondrial biogenesis and function

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Inhibitory effect of Bcl-2 on p53-mediated transactivation following genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Regulation of p53 downstream genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 modulation of TFIIH-associated nucleotide excision repair activity

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 protein at the hub of cellular DNA damage response pathways through sequence-specific and non-sequence-specific DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Increase of spontaneous intrachromosomal homologous recombination in mammalian cells expressing a mutant p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Inactivation of p53 results in high rates of homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Interaction of p53 with the human Rad51 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 Protein exhibits 3'-to-5' exonuclease activity

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Different regulation of the p53 core domain activities 3'-to-5' exonuclease and sequence-specific DNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

A novel role for the Bcl-2 protein family: specific suppression of the RAD51 recombination pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The contribution of homologous recombination in preserving genome integrity in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

PolyADP-ribose-mediated regulation of p53 complexed with topoisomerase I following ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Binding of wild-type p53 by topoisomerase II and overexpression of topoisomerase II in human hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Human topoisomerase IIalpha and IIbeta interact with the C-terminal region of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

A comparison of the biological activities of wild-type and mutant p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Structure, function and regulation of p63 and p73.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

1 reference

7 January 2021

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The INK4A/ARF locus and its two gene products

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The interaction between p53 and papillomaviruses

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The role of the E6-p53 interaction in the molecular pathogenesis of HPV.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

DNA-sequence specificity of mutations at the human thymidine kinase locus

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The relative radiosensitivity of TK6 and WI-L2-NS lymphoblastoid cells derived from a common source is primarily determined by their p53 mutational status

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Cytotoxic and mutagenic responses to X-rays and chemical mutagens in normal and p53-mutated human lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Illegitimate recombination leading to allelic loss and unbalanced translocation in p53-mutated human lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Requirement of wild-type p53 protein for maintenance of chromosomal integrity

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

A mutation in the p53 tumor suppressor gene of AHH-1 tk+/- human lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Evaluation of the genotoxicity of the phytoestrogen, coumestrol, in AHH-1 TK(+/-) human lymphoblastoid cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The influence of cellular apoptotic capacity on N-nitrosodimethylamine-induced loss of heterozygosity mutations in human cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Rearrangement of the p53 gene in human osteogenic sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Decrease in the frequency of X-ray-induced mutation by wild-type p53 protein in human osteosarcoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Reduced UV-induced mutations in human osteosarcoma cells stably expressing transfected wild-type p53 cDNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Induction of p53 in mouse cells decreases mutagenesis by UV radiation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Insights into cancer from transgenic mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Spontaneous mutation frequencies and spectra in p53 (+/+) and p53 (-/-) mice: a test of the 'guardian of the genome' hypothesis in the Big Blue transgenic mouse mutation detection system.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

p53 deficiency does not affect the accumulation of point mutations in a transgene target

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Chromosome instability contributes to loss of heterozygosity in mice lacking p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

High-frequency genetic reversion mediated by a DNA duplication: the mouse pink-eyed unstable mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Reversion of the mouse pink-eyed unstable mutation induced by low doses of x-rays.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Involvement of p53 in X-ray induced intrachromosomal recombination in mice

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Absence of p53 permits propagation of mutant cells following genotoxic damage

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Mutant p53 protein expression interferes with p53-independent apoptotic pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

High metastatic potential in mice inheriting a targeted p53 missense mutation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2801%2900075-8

7 January 2021

10.1016/S1383-5742(01)00075-8

Identifiers

DOI

1 reference

3 August 2017

1 reference

PubMed ID

11906841