The p53 protein is an unusually shaped tetramer that binds directly to DNA. (Q36237614)

12 August 2017

The p53 protein is an unusually shaped tetramer that binds directly to DNA. (English)

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12 August 2017

P N Friedman

1

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12 August 2017

X Chen

series ordinal

2

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12 August 2017

J Bargonetti

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3

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12 August 2017

C Prives

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4

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12 August 2017

1 April 1993

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Proceedings of the National Academy of Sciences of the United States of America

12 August 2017

language of work or name

English

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published in

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12 August 2017

90

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12 August 2017

8

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12 August 2017

3319-3323

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Oligomerization of oncoprotein p53.

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Protein folding and intracellular transport: evaluation of conformational changes in nascent exocytotic proteins.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

A potential transcriptional activation element in the p53 protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Structural aspects of the p53 protein in relation to gene evolution

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Identification of p53 as a sequence-specific DNA-binding protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

A DNA binding domain is contained in the C-terminus of wild type p53 protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

p53 mutations in human cancers

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Oncogenic forms of p53 inhibit p53-regulated gene expression

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

A transcriptionally active DNA-binding site for human p53 protein complexes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Mammalian p53 can function as a transcription factor in yeast

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Definition of a consensus binding site for p53

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Presence of a potent transcription activating sequence in the p53 protein

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

Formation of stable p53 homotetramers and multiples of tetramers

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=46291

SV40 T antigen binds specifically to a cellular 53 K protein in vitro

29 June 2018

1 reference

12 December 2020

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1 reference

12 December 2020

Biochemical and biophysical characterization of the reovirus cell attachment protein sigma 1: evidence that it is a homotrimer

1 reference

12 December 2020

Constitution of the twin polymerase of DNA polymerase III holoenzyme

1 reference

12 December 2020

Wild-type p53 activates transcription in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.90.8.3319

1 reference

release_chqgf5ddqneqfbhmedqenvi64a

12 August 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/chqgf5ddqneqfbhmedqenvi64a

24 November 2022

mapped directly with Wikidata item

1 reference

12 August 2017

PubMed publication ID

8475074

1 reference