Protein-misfolding diseases and chaperone-based therapeutic approaches (Q34524526)

2 August 2017

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title

Protein-misfolding diseases and chaperone-based therapeutic approaches (English)

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2 August 2017

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Tapan K Chaudhuri

1

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PubMed ID

16689923

2 August 2017

Subhankar Paul

series ordinal

2

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PubMed ID

16689923

2 August 2017

language of work or name

English

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publication date

1 April 2006

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2 August 2017

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2 August 2017

273

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2 August 2017

1331-1349

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2 August 2017

7

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Medicine: danger--misfolding proteins.

2 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Therapeutic approaches to protein-misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Influence of molecular and chemical chaperones on protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

'Unfolding' pathways in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Chaperone overload is a possible contributor to 'civilization diseases'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Aggresomes, inclusion bodies and protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Protein misfolding, evolution and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Chemical chaperones correct the mutant phenotype of the delta F508 cystic fibrosis transmembrane conductance regulator protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Molecular basis of the neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Protein misfolding and disease; protein refolding and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Kinetic theory of fibrillogenesis of amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Defective protein folding as a basis of human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Pathologic conformations of prion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Alternative conformations of amyloidogenic proteins govern their behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Review: mechanisms of disaggregation and refolding of stable protein aggregates by molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

From Alzheimer to Huntington: why is a structural understanding so difficult?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Protein misfolding in Alzheimer's and Parkinson's disease: genetics and molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Neurodegenerative disorders of protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Recent advances in the genetics and pathogenesis of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Review: formation and properties of amyloid-like fibrils derived from alpha-synuclein and related proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

alpha-synuclein promotes mitochondrial deficit and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Alpha-synuclein and Parkinson's disease: selective neurodegenerative effect of alpha-synuclein fragment on dopaminergic neurons in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Shattuck lecture--neurodegenerative diseases and prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

High level expression of expanded full-length ataxin-3 in vitro causes cell death and formation of intranuclear inclusions in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Autosomal dominant cerebellar ataxia: phenotypic differences in genetically defined subtypes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the alpha 1A-voltage-dependent calcium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Molecular and clinical correlations in autosomal dominant cerebellar ataxia with progressive macular dystrophy (SCA7).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

The cystic fibrosis transmembrane conductance regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Structural aspects of the p53 protein in relation to gene evolution: a second look.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

A point mutation of the rhodopsin gene in one form of retinitis pigmentosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Alternative splicing in the alpha-galactosidase A gene: increased exon inclusion results in the Fabry cardiac phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Protective effect of chaperones on polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Chemical chaperones reduce aggregate formation and cell death caused by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Chemical chaperones increase the cellular activity of N370S beta -glucosidase: a therapeutic strategy for Gaucher disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Potent inhibition of scrapie prion replication in cultured cells by bis-acridines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Therapeutic approaches to repair defects in deltaF508 CFTR folding and cellular targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Pharmacological chaperones: a new twist on receptor folding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Examination of the Structure of the Transthyretin Amyloid Fibril by Image Reconstruction from Electron Micrographs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2006.05181.X

10.1111/J.1742-4658.2006.05181.X

21 January 2018

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

16689923