Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. (Q45296540)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

title

Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

main subject

Drosophila

0 references

photoreceptor protein

0 references

author

Iris Salecker

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

author name string

G R Jackson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

X Dong

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

X Yao

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

N Arnheim

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

P W Faber

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

M E MacDonald

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

S L Zipursky

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

language of work or name

English

0 references

publication date

1 September 1998

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

volume

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

page(s)

633-642

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9768849%20AND%20SRC:MED&resulttype=core&format=json

Virus-like particles in normal and tumorous tissues of Drosophila

5 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Structure and expression of the Huntington's disease gene: evidence against simple inactivation due to an expanded CAG repeat

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

SCA1 transgenic mice: A model for neurodegeneration caused by an expanded CAG trinucleotide repeat

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

grim, a novel cell death gene in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Control of programmed cell death by the baculovirus genes p35 and iap.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Inactivation of the mouse Huntington's disease gene homolog Hdh

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Nuclear Inclusions: A Study of Aging in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Huntington's disease: CAG genetics expands neurobiology

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Deletion of Huntington's disease-linked G8 (D4S10) locus in Wolf-Hirschhorn syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Spinocerebellar ataxia, type 3 (SCA3) is genetically identical to Machado-Joseph disease (MJD)

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

The fatal attraction of polyglutamine-containing proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Mutations in American families with spinocerebellar ataxia (SCA) type 3: SCA3 is allelic to Machado-Joseph disease

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Spinocerebellar ataxia type 7 (SCA7): a neurodegenerative disorder with neuronal intranuclear inclusions.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Characterization and localization of the Huntington disease gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Suppression of aggregate formation and apoptosis by transglutaminase inhibitors in cells expressing truncated DRPLA protein with an expanded polyglutamine stretch.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Episodic ataxia type 2 (EA2) and spinocerebellar ataxia type 6 (SCA6) due to CAG repeat expansion in the CACNA1A gene on chromosome 19p

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Evidence from antibody studies that the CAG repeat in the Huntington disease gene is expressed in the protein

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Retinal degeneration caused by dominant rhodopsin mutations in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Huntington's disease. Pathogenesis and management

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Production of virus-like particles by the transposable genetic element, copia, of Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouse.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Intranuclear inclusions of expanded polyglutamine protein in spinocerebellar ataxia type 3.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

The ultrastructure of imaginal disc cells in primary cultures and during cell aggregation in continuous cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

SCA6 is caused by moderate CAG expansion in the alpha1A-voltage-dependent calcium channel gene

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Embryonic development of the antennal lobes of a hemimetabolous insect, the cockroach Periplaneta americana: light and electron microscopic observations

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Identification of the spinocerebellar ataxia type 2 gene using a direct identification of repeat expansion and cloning technique, DIRECT.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Huntingtin localization in brains of normal and Huntington's disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Widespread expression of Huntington's disease gene (IT15) protein product

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Transposition of cloned P elements into Drosophila germ line chromosomes.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Programmed cell death in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Ataxin-3 is transported into the nucleus and associates with the nuclear matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Cell killing by the Drosophila gene reaper.

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Cell death: the significance of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

The compound eye in the opaque-eye phenotype ofDrosophila melanogaster

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

1 reference

https://api.crossref.org/works/10.1016%2FS0896-6273%2800%2980573-5

7 January 2021