CHK2 kinase--a busy messenger. (Q34457165)

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4 December 2019

review article

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title

CHK2 kinase--a busy messenger (English)

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4 December 2019

3

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4 December 2019

author name string

Bartek J

series ordinal

1

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4 December 2019

Falck J

series ordinal

2

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4 December 2019

publication date

1 December 2001

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Nature Reviews Molecular Cell Biology

4 December 2019

published in

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4 December 2019

volume

2

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4 December 2019

page(s)

877-886

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4 December 2019

issue

12

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https://scigraph.springernature.com/pub.10.1038/35103059

4 December 2019

exact match

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cites work

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Cell cycle control and cancer

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Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

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Sensing and responding to DNA damage.

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DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

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DNA double-strand breaks: signaling, repair and the cancer connection

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

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Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53

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Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

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Checkpoints: controls that ensure the order of cell cycle events

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

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A kinase from fission yeast responsible for blocking mitosis in S phase.

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Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends

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Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair.

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Critical role of Caenorhabditis elegans homologs of Cds1 (Chk2)-related kinases in meiotic recombination

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Nuclear reorganization and homologous chromosome pairing during meiotic prophase require C. elegans chk-2.

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A novel Drosophila nuclear protein serine/threonine kinase expressed in the germline during its establishment.

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A meiosis-specific protein kinase homolog required for chromosome synapsis and recombination

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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

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Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1.

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Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1

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The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

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Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

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Kinase interaction domain of kinase-associated protein phosphatase, a phosphoprotein-binding domain

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The FHA domain is a modular phosphopeptide recognition motif.

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The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

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7 January 2021

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

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7 January 2021

Budding yeast Rad9 is an ATP-dependent Rad53 activating machine.

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7 January 2021

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks

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7 January 2021

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

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7 January 2021

Mrc1 transduces signals of DNA replication stress to activate Rad53.

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Mrc1 channels the DNA replication arrest signal to checkpoint kinase Cds1.

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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Surfing the p53 network

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Regulation and function of the p53 tumor suppressor protein

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

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In search of the tumour-suppressor functions of BRCA1 and BRCA2

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

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7 January 2021

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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7 January 2021

Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

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7 January 2021

DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding

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7 January 2021

Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding.

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7 January 2021

The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

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7 January 2021

Rapid destruction of human Cdc25A in response to DNA damage

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7 January 2021

Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis

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7 January 2021

The Mre11 complex and ATM: collaborating to navigate S phase

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7 January 2021

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7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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7 January 2021

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

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7 January 2021

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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7 January 2021

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

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7 January 2021

ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation.

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7 January 2021

Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours

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7 January 2021

Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes

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7 January 2021

Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase

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7 January 2021

Mammalian G1- and S-phase checkpoints in response to DNA damage

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7 January 2021

Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

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7 January 2021

Screening hCHK2 for Mutations

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7 January 2021

Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias

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7 January 2021

Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.

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7 January 2021

Characterization of tumor-associated Chk2 mutations

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7 January 2021

Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase

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7 January 2021

ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation

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7 January 2021

UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

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7 January 2021

The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

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7 January 2021

Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase

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7 January 2021

Identifiers

DOI

10.1038/35103059

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11733767%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 December 2019

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