Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo. (Q34431008)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25217640%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo (English)

1 reference

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16 February 2020

0 references

4

1 reference

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16 February 2020

Mary J LaDu

9

1 reference

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16 February 2020

author name string

Leon M Tai

1

1 reference

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16 February 2020

Kevin P Koster

2

1 reference

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16 February 2020

Jia Luo

3

1 reference

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16 February 2020

Yue-ting Wang

5

1 reference

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16 February 2020

Nicole C Collins

6

1 reference

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16 February 2020

Manel Ben Aissa

7

1 reference

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16 February 2020

Gregory R J Thatcher

8

1 reference

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16 February 2020

language of work or name

English

0 references

publication date

12 September 2014

1 reference

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16 February 2020

number of pages

18

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

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16 February 2020

volume

289

1 reference

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16 February 2020

issue

44

1 reference

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16 February 2020

page(s)

30538-30555

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25217640%20AND%20SRC:MED&resulttype=core&format=json

Genetic modulation of soluble Aβ rescues cognitive and synaptic impairment in a mouse model of Alzheimer's disease

16 February 2020

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Modeling, synthesis, and biological evaluation of potential retinoid X receptor (RXR) selective agonists: novel analogues of 4-[1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic acid (bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro

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Comment on "ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models"

6 July 2018

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ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

6 July 2018

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Binding of apolipoprotein E inhibits the oligomer growth of amyloid-β peptide in solution as determined by fluorescence cross-correlation spectroscopy

6 July 2018

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Accelerated cell aging in female APOE-ε4 carriers: implications for hormone therapy use

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Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples

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6 July 2018

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Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

6 July 2018

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6 July 2018

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6 July 2018

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Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women.

6 July 2018

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6 July 2018

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Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells

6 July 2018

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The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

6 July 2018

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Antiamyloid therapy for Alzheimer's disease--are we on the right road?

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ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

21 January 2018

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The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

21 January 2018

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Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

21 January 2018

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Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

21 January 2018

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Reversal of apoE4-driven brain pathology and behavioral deficits by bexarotene.

21 January 2018

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Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat.

21 January 2018

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Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein

21 January 2018

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Synthesis of novel retinoid X receptor-selective retinoids.

21 January 2018

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Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

21 January 2018

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Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

21 January 2018

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Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

21 January 2018

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apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

21 January 2018

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β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.

21 January 2018

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Estrogen use, APOE, and cognitive decline: evidence of gene-environment interaction

21 January 2018

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Ten-year experience of bexarotene therapy for cutaneous T-cell lymphoma in Finland

21 January 2018

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Functional impairment in alcoholic liver disease and non-alcoholic fatty liver disease is significant and persists over 3 years of follow-up

21 January 2018

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21 January 2018

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Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".

27 October 2018

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Suppression of mammary tumorigenesis in transgenic mice by the RXR-selective retinoid, LGD1069.

27 October 2018

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Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors.

27 October 2018

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Evidence for an interaction between apolipoprotein E genotype, gender, and Alzheimer disease.

27 October 2018

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Detection of impaired cognitive function in rat with hepatosteatosis model and improving effect of GLP-1 analogs (exenatide) on cognitive function in hepatosteatosis

27 October 2018

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Organ-specific expression profiles of rat mammary gland, liver, and lung tissues treated with targretin, 9-cis retinoic acid, and 4-hydroxyphenylretinamide

21 January 2018

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12 December 2020

Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation

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12 December 2020

2013 Alzheimer's disease facts and figures

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Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

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Identifiers

DOI

10.1074/JBC.M114.600833

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25217640%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25217640%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference