Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. (Q45993868)

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29 January 2020

title

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice (English)

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29 January 2020

author name string

Kelly R Bales

1

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29 January 2020

Feng Liu

2

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29 January 2020

Su Wu

3

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29 January 2020

Suizhen Lin

4

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29 January 2020

Deanna Koger

5

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29 January 2020

Cynthia DeLong

6

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29 January 2020

Jeffrey C Hansen

7

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29 January 2020

Patrick M Sullivan

8

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29 January 2020

Steven M Paul

9

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29 January 2020

language of work or name

English

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publication date

1 May 2009

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29 January 2020

published in

Journal of Neuroscience

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29 January 2020

volume

29

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29 January 2020

page(s)

6771-6779

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29 January 2020

issue

21

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Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

29 January 2020

cites work

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Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease.

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Cognitive change and the APOE epsilon 4 allele

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Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system

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Apolipoprotein E dose-dependent modulation of beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease

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ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

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Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein

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Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

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The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I.

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Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-beta

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The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

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Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.

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Effect of domain interaction on apolipoprotein E levels in mouse brain.

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Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target

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Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency.

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

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Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

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ApoE promotes the proteolytic degradation of Abeta

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12 December 2020

Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression

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12 December 2020

Apolipoprotein E represents a potent gene-based therapeutic target for the treatment of sporadic Alzheimer's disease

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12 December 2020

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels

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12 December 2020

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

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12 December 2020

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

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Genetics of the apolipoprotein E system in man

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Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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12 December 2020

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12 December 2020

Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis

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12 December 2020

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

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12 December 2020

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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12 December 2020

Nascent astrocyte particles differ from lipoproteins in CSF.

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12 December 2020

APOE genotype predicts when--not whether--one is predisposed to develop Alzheimer disease.

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12 December 2020

Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease

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12 December 2020

10.1523/JNEUROSCI.0887-09.2009

Identifiers

DOI

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