The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine. (Q34352431)

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14 February 2020

title

The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine (English)

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14 February 2020

5

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14 February 2020

Stefan G. Sarafianos

series ordinal

7

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14 February 2020

Eiichi Kodama

series ordinal

4

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14 February 2020

3

Atsuko Hachiya

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14 February 2020

1

Matthew M Schuckmann

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14 February 2020

6

Kamalendra Singh

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14 February 2020

author name string

Bruno Marchand

series ordinal

2

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14 February 2020

language of work or name

English

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publication date

27 September 2010

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Journal of Biological Chemistry

14 February 2020

published in

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14 February 2020

volume

285

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14 February 2020

issue

49

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14 February 2020

page(s)

38700-38709

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N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation

14 February 2020

cites work

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A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.

6 July 2018

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Combinations of mutations in the connection domain of human immunodeficiency virus type 1 reverse transcriptase: assessing the impact on nucleoside and nonnucleoside reverse transcriptase inhibitor resistance

6 July 2018

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Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase

6 July 2018

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N348I in reverse transcriptase provides a genetic pathway for HIV-1 to select thymidine analogue mutations and mutations antagonistic to thymidine analogue mutations

6 July 2018

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N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations

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Clinical relevance of substitutions in the connection subdomain and RNase H domain of HIV-1 reverse transcriptase from a cohort of antiretroviral treatment-naïve patients

6 July 2018

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Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition

6 July 2018

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HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

6 July 2018

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Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms

6 July 2018

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Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

6 July 2018

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N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

6 July 2018

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Relationship of potency and resilience to drug resistant mutations for GW420867X revealed by crystal structures of inhibitor complexes for wild-type, Leu100Ile, Lys101Glu, and Tyr188Cys mutant HIV-1 reverse transcriptases

6 July 2018

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Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance

6 July 2018

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Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases

6 July 2018

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Novel mechanism of inhibition of HIV-1 reverse transcriptase by a new non-nucleoside analog, KM-1.

6 July 2018

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Antiviral drugs in current clinical use.

6 July 2018

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Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

6 July 2018

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Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.

6 July 2018

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Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase

6 July 2018

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Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

6 July 2018

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Enhanced impairment of chain elongation by inhibitors of HIV reverse transcriptase in cell-free reactions yielding longer DNA products

6 July 2018

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Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

6 July 2018

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

6 July 2018

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Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

6 July 2018

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Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity

6 July 2018

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Conferring RNA polymerase activity to a DNA polymerase: a single residue in reverse transcriptase controls substrate selection

6 July 2018

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Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant

6 July 2018

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Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis

6 July 2018

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Structure of unliganded HIV-1 reverse transcriptase at 2.7 A resolution: implications of conformational changes for polymerization and inhibition mechanisms

6 July 2018

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Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization

6 July 2018

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The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

6 July 2018

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Human immunodeficiency virus reverse transcriptase substrate-induced conformational changes and the mechanism of inhibition by nonnucleoside inhibitors

6 July 2018

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High resolution structures of HIV-1 RT from four RT-inhibitor complexes

6 July 2018

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Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

6 July 2018

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The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

6 July 2018

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Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase

6 July 2018

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Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

6 July 2018

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Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant

6 July 2018

1 reference

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

6 July 2018

1 reference

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Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir

6 July 2018

1 reference

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Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

21 January 2018

1 reference

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Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.153783

Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.153783

Antiretroviral drug resistance

21 January 2018

1 reference

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Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity

21 January 2018

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12 December 2020

HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors

1 reference

12 December 2020

Mutating a conserved motif of the HIV-1 reverse transcriptase palm subdomain alters primer utilization

1 reference

12 December 2020

Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function

1 reference

12 December 2020

Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.153783

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876531%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20876531%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference