Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC. (Q44486147)

3 December 2017

Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC. (English)

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3 December 2017

2

Karidia Diallo

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3 December 2017

Mélanie Girouard

1

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3 December 2017

Bruno Marchand

series ordinal

3

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3 December 2017

Suzanne McCormick

series ordinal

4

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3 December 2017

Matthias Götte

series ordinal

5

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3 December 2017

language of work or name

English

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publication date

20 June 2003

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Journal of Biological Chemistry

3 December 2017

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3 December 2017

278

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3 December 2017

36

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3 December 2017

34403-34410

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Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

3 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303528200

Biochemical mechanisms involved in overcoming HIV resistance to nucleoside inhibitors of reverse transcriptase

21 January 2018

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Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

21 January 2018

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High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

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The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

21 January 2018

1 reference

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Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

21 January 2018

1 reference

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

21 January 2018

1 reference

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Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303528200

Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

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ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase

21 January 2018

1 reference

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The M184V mutation in the reverse transcriptase of human immunodeficiency virus type 1 impairs rescue of chain-terminated DNA synthesis

21 January 2018

1 reference

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Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues

21 January 2018

1 reference

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Prevalence and conditions of selection of E44D/A and V118I human immunodeficiency virus type 1 reverse transcriptase mutations in clinical practice

21 January 2018

1 reference

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A novel human immunodeficiency virus type 1 reverse transcriptase mutational pattern confers phenotypic lamivudine resistance in the absence of mutation 184V

21 January 2018

1 reference

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Antiretroviral resistance during successful therapy of HIV type 1 infection.

21 January 2018

1 reference

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Prevalence of the mutational pattern E44D/A and/or V118I in the reverse transcriptase (RT) gene of HIV-1 in relation to treatment with nucleoside analogue RT inhibitors

21 January 2018

1 reference

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Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118.

21 January 2018

1 reference

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Phenotypic and genotypic analysis of biologically cloned human immunodeficiency virus type 1 isolates from patients treated with zidovudine and lamivudine

21 January 2018

1 reference

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Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.

21 January 2018

1 reference

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Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP.

21 January 2018

1 reference

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Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site

21 January 2018

1 reference

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Patterns of resistance mutations selected by treatment of human immunodeficiency virus type 1 infection with zidovudine, didanosine, and nevirapine

21 January 2018

1 reference

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Correlation between viral resistance to zidovudine and resistance at the reverse transcriptase level for a panel of human immunodeficiency virus type 1 mutants

21 January 2018

1 reference

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Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

21 January 2018

1 reference

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Prediction of abacavir resistance from genotypic data: impact of zidovudine and lamivudine resistance in vitro and in vivo

21 January 2018

1 reference

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

21 January 2018

1 reference

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Analysis of mutations at positions 115 and 116 in the dNTP binding site of HIV-1 reverse transcriptase.

21 January 2018

1 reference

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The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues

21 January 2018

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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

21 January 2018

1 reference

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Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.

21 January 2018

1 reference

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The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M303528200

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

21 January 2018

1 reference

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Helicobacter pylori urease significantly reduces opsonization by human complement

21 January 2018

1 reference

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Analysis of efficiency and fidelity of HIV-1 (+)-strand DNA synthesis reveals a novel rate-limiting step during retroviral reverse transcription

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M303528200

1 reference

3 December 2017

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