Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis (Q35907177)

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scientific article published in August 1996

Language	Label	Description	Also known as
English	Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis	scientific article published in August 1996

Statements

scholarly article

1 reference

Europe PubMed Central

11 August 2017

Human immunodeficiency virus type 1 reverse transcriptase: role of Tyr115 in deoxynucleotide binding and misinsertion fidelity of DNA synthesis (English)

1 reference

Europe PubMed Central

11 August 2017

author name string

Martín-Hernández AM

1

1 reference

Europe PubMed Central

11 August 2017

Domingo E

2

1 reference

Europe PubMed Central

11 August 2017

Menéndez-Arias L

3

1 reference

Europe PubMed Central

11 August 2017

language of work or name

0 references

publication date

1 August 1996

1 reference

Europe PubMed Central

11 August 2017

The EMBO Journal

1 reference

Europe PubMed Central

11 August 2017

15

1 reference

Europe PubMed Central

11 August 2017

16

1 reference

Europe PubMed Central

11 August 2017

4434-4442

1 reference

Europe PubMed Central

11 August 2017

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The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design

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Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents

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Mutational studies of human DNA polymerase alpha. Identification of residues critical for deoxynucleotide binding and misinsertion fidelity of DNA synthesis.

1 reference

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Pol gene quasispecies of human immunodeficiency virus: mutations associated with drug resistance in virus from patients undergoing no drug therapy

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Identification of the nucleotide binding site of HIV-1 reverse transcriptase using dTTP as a photoaffinity label

1 reference

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E. coli DNA polymerase I as a reverse transcriptase

1 reference

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Human immunodeficiency virus type 1 reverse transcriptase tG:T mispair formation on RNA and DNA templates with mismatched primers: a kinetic and thermodynamic study.

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Structure of HIV-1 reverse transcriptase in a complex with the non-nucleoside inhibitor alpha-APA R 95845 at 2.8 A resolution

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Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

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Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase

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The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

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Human immunodeficiency virus-1 reverse transcriptase heterodimer stability

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Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

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Misincorporation and mispaired primer extension by human immunodeficiency virus reverse transcriptase

1 reference

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Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

1 reference

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Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase

1 reference

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Elementary steps in the DNA polymerase I reaction pathway

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DNA polymerase insertion fidelity. Gel assay for site-specific kinetics

1 reference

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Complete nucleotide sequence of the AIDS virus, HTLV-III

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Identification of four conserved motifs among the RNA-dependent polymerase encoding elements

1 reference

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Extension of mismatched 3' termini of DNA is a major determinant of the infidelity of human immunodeficiency virus type 1 reverse transcriptase.

1 reference

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Co-expression of the subunits of the heterodimer of HIV-1 reverse transcriptase in Escherichia coli.

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Substrate binding in human immunodeficiency virus reverse transcriptase. An analysis of pyridoxal 5'-phosphate sensitivity and identification of lysine 263 in the substrate-binding domain

1 reference

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Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis, and template switching

1 reference

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Fidelity of human immunodeficiency virus type I reverse transcriptase in copying natural DNA.

1 reference

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The accuracy of reverse transcriptase from HIV-1.

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Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants

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Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.

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An attempt to unify the structure of polymerases

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A general structure for DNA-dependent DNA polymerases.

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A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity

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Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase

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Human immunodeficiency virus reverse transcriptase. Effect of primer length on template-primer binding

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Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase

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Human immunodeficiency virus reverse transcriptase. Substrate and inhibitor kinetics with thymidine 5'-triphosphate and 3'-azido-3'-deoxythymidine 5'-triphosphate

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Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent

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Unequal human immunodeficiency virus type 1 reverse transcriptase error rates with RNA and DNA templates

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

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Comparison of HIV-1 and avian myeloblastosis virus reverse transcriptase fidelity on RNA and DNA templates

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Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1

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Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis.

1 reference

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine

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Monoclonal antibody-mediated inhibition of HIV-1 reverse transcriptase polymerase activity. Interaction with a possible deoxynucleoside triphosphate binding domain.

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Biochemical analysis of human immunodeficiency virus-1 reverse transcriptase containing a mutation at position lysine 263.

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Reduced frameshift fidelity and processivity of HIV-1 reverse transcriptase mutants containing alanine substitutions in helix H of the thumb subdomain.

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Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase

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Fidelity of HIV-1 reverse transcriptase

1 reference

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Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase

1 reference

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12 December 2020

based on heuristic

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Site-directed mutagenesis of arginine 72 of HIV-1 reverse transcriptase. Catalytic role and inhibitor sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8861970

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based on heuristic

inferred from PubMed ID database lookup

Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase

1 reference

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based on heuristic

inferred from PubMed ID database lookup

A possible role for cysteine residues in the fidelity of DNA synthesis exhibited by the reverse transcriptases of human immunodeficiency viruses type 1 and type 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/8861970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phi 29 DNA polymerase active site. Mutants in conserved residues Tyr254 and Tyr390 are affected in dNTP binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/8861970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic analysis of template.primer interactions with recombinant forms of HIV-1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8861970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

Europe PubMed Central

11 August 2017

1 reference

Europe PubMed Central

11 August 2017

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