N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance (Q28471689)

4

object named as

Mark Zanin

0 references

Nicolas Sluis-Cremer

9

object named as

Nicolas Sluis-Cremer

0 references

author name string

Soo-Huey Yap

1

0 references

Chih-Wei Sheen

2

0 references

Jonathan Fahey

3

0 references

David Tyssen

5

0 references

Viviane Dias Lima

6

0 references

Brian Wynhoven

7

0 references

Michael Kuiper

8

0 references

P Richard Harrigan

HIV-1 subtype B protease and reverse transcriptase amino acid covariation

10

0 references

language of work or name

English

0 references

publication date

December 2007

0 references

published in

PLOS MEDICINE

0 references

volume

4

0 references

page(s)

e335

0 references

issue

12

0 references

cites work

1 reference

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Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol

19 March 2017

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Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART

19 March 2017

1 reference

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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

19 March 2017

1 reference

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

19 March 2017

1 reference

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Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

19 March 2017

1 reference

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A novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2',3'-dideoxy-3'-thiacytidine

19 March 2017

1 reference

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An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine

19 March 2017

1 reference

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Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility

19 March 2017

1 reference

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Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods

19 March 2017

1 reference

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L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

19 March 2017

1 reference

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The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

19 March 2017

1 reference

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Human immunodeficiency virus type 1 pol gene mutations in an AIDS patient treated with multiple antiretroviral drugs

19 March 2017

1 reference

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Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

19 March 2017

1 reference

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Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors

19 March 2017

1 reference

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Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors

19 March 2017

1 reference

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High resolution structures of HIV-1 RT from four RT-inhibitor complexes

19 March 2017

1 reference

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Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

19 March 2017

1 reference

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High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

19 March 2017

1 reference

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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

19 March 2017

1 reference

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Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase

19 March 2017

1 reference

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Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine

19 March 2017

1 reference

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Mechanism and fidelity of HIV reverse transcriptase

19 March 2017

1 reference

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Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

19 March 2017

1 reference

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

7 April 2017

1 reference

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Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy.

7 April 2017

1 reference

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

7 April 2017

1 reference

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Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay

7 April 2017

1 reference

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Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

7 April 2017

1 reference

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Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance

29 September 2017

1 reference

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Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance

29 September 2017

1 reference

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Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors

29 September 2017

1 reference

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Structure-activity relationships of [2',5'-bis-O-(tert-butyldimethylsilyl)-beta-D-ribofuranosyl]- 3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine derivatives as inhibitors of HIV-1 reverse transcriptase dimerization.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

Mutations that abrogate human immunodeficiency virus type 1 reverse transcriptase dimerization affect maturation of the reverse transcriptase heterodimer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

The 3'-azido group is not the primary determinant of 3'-azido-3'-deoxythymidine (AZT) responsible for the excision phenotype of AZT-resistant HIV-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

Adherence and plasma HIV RNA responses to highly active antiretroviral therapy among HIV-1 infected injection drug users

29 September 2017

1 reference

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A mutation in the 3' region of the human immunodeficiency virus type 1 reverse transcriptase (Y318F) associated with nonnucleoside reverse transcriptase inhibitor resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100143

Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs).

29 September 2017

1 reference

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Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy

29 September 2017

1 reference

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Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

29 September 2017

1 reference

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A recombinant retroviral system for rapid in vivo analysis of human immunodeficiency virus type 1 susceptibility to reverse transcriptase inhibitors

29 September 2017

1 reference

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Zidovudine resistance is suppressed by mutations conferring resistance of human immunodeficiency virus type 1 to foscarnet.

29 September 2017

1 reference

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Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

29 September 2017

1 reference

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Comparison of deoxyoligonucleotide and tRNA(Lys-3) as primers in an endogenous human immunodeficiency virus-1 in vitro reverse transcription/template-switching reaction

29 September 2017

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Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors

29 September 2017

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Mutational analysis of Lys65 of HIV-1 reverse transcriptase

2 June 2018

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Identification of accessory mutations associated with high-level resistance in HIV-1 reverse transcriptase.

2 June 2018

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27 November 2018

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Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine

27 November 2018

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Mutations E44D and V118I in the reverse transcriptase of HIV-1 play distinct mechanistic roles in dual resistance to AZT and 3TC.

27 November 2018

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Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy.

27 November 2018

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Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity.

27 November 2018

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Prevalence of G333D/E in naive and pretreated HIV-infected patients

27 November 2018

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Mechanism by which phosphonoformic acid resistance mutations restore 3'-azido-3'-deoxythymidine (AZT) sensitivity to AZT-resistant HIV-1 reverse transcriptase.

27 November 2018

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Prevalence of primary HIV drug resistance among seroconverters during an explosive outbreak of HIV infection among injecting drug users

27 November 2018

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Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase

27 November 2018

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27 November 2018

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Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance.

27 November 2018

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A molecular clone of HTLV-III with biological activity.

27 November 2018

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Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.

27 November 2018

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Adherence to triple therapy and viral load response

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18052601

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

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