JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling (Q34260055)

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English	JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling	scientific article

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scholarly article

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Europe PubMed Central

1 August 2017

JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling (English)

1 reference

Europe PubMed Central

1 August 2017

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based on heuristic

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author name string

Saida Abdelli

1

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Europe PubMed Central

1 August 2017

Christophe Bonny

2

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Europe PubMed Central

1 August 2017

language of work or name

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publication date

1 May 2012

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Europe PubMed Central

1 August 2017

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Europe PubMed Central

1 August 2017

7

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Europe PubMed Central

1 August 2017

5

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Europe PubMed Central

1 August 2017

e35997

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Europe PubMed Central

1 August 2017

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Creative Commons Attribution 4.0 International

1 May 2012

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April 2022 Public Data File from Crossref

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FoxO feedback control of basal IRS-2 expression in pancreatic β-cells is distinct from that in hepatocytes

1 reference

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6 July 2018

Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3β independent of JNK activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

Exendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3β activity

1 reference

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6 July 2018

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

1 reference

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6 July 2018

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

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6 July 2018

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance

1 reference

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6 July 2018

The emerging role of FOXO transcription factors in pancreatic beta cells.

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6 July 2018

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

1 reference

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6 July 2018

Physiological roles of PKB/Akt isoforms in development and disease

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6 July 2018

Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells

1 reference

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6 July 2018

Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms

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6 July 2018

Mechanisms of beta-cell death in type 2 diabetes.

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6 July 2018

Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

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6 July 2018

Recent advances in the protein kinase B signaling pathway

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6 July 2018

Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells

1 reference

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6 July 2018

PTEN regulatory functions in tumor suppression and cell biology

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6 July 2018

Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?

1 reference

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6 July 2018

The glamour and gloom of glycogen synthase kinase-3

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6 July 2018

Physiological functions of protein kinase B/Akt

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6 July 2018

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28 October 2018

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

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6 July 2018

Physiological functions of Pten in mouse tissues

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6 July 2018

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

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6 July 2018

The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

A central role for JNK in obesity and insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

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6 July 2018

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

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6 July 2018

A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis

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6 July 2018

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

beta-cell apoptosis: stimuli and signaling

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

IRS proteins and beta-cell function

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death

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6 July 2018

Signal transduction by the JNK group of MAP kinases

1 reference

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6 July 2018

Cellular signaling: pivoting around PDK-1.

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6 July 2018

The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

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6 July 2018

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

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6 July 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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6 July 2018

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

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6 July 2018

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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6 July 2018

Disruption of IRS-2 causes type 2 diabetes in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3341388

6 July 2018

The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action

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6 July 2018

PDK1, one of the missing links in insulin signal transduction?

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6 July 2018

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

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6 July 2018

The role of interleukin-1 in the pathogenesis of IDDM.

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6 July 2018

Selective interaction of JNK protein kinase isoforms with transcription factors

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6 July 2018

c-jun inhibits insulin control element-mediated transcription by affecting the transactivation potential of the E2A gene products

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6 July 2018

Cloning, chromosomal localization and expression analysis of the mouse Akt2 oncogene.

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6 July 2018

Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines

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6 July 2018

Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets

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21 January 2018

Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase.

1 reference

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21 January 2018

The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis

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21 January 2018

JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

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21 January 2018

Intracellular Stress Signaling Pathways Activated During Human Islet Preparation and Following Acute Cytokine Exposure

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21 January 2018

Insulin signaling in health and disease

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase B is expressed in pancreatic beta cells and activated upon stimulation with insulin-like growth factor I

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of c-jun N terminal kinase (JNK) improves functional beta cell mass in human islets and leads to AKT and glycogen synthase kinase-3 (GSK-3) phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22563476

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0035997

1 reference

Europe PubMed Central

1 August 2017

2012PLoSO...735997A

0 references

1 reference

Europe PubMed Central

1 August 2017

1 reference

Europe PubMed Central

1 August 2017

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