BH3-only molecule Bim mediates β-cell death in IRS2 deficiency. (Q34227850)

31 July 2017

BH3-only molecule Bim mediates β-cell death in IRS2 deficiency. (English)

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31 July 2017

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Decheng Ren

1

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31 July 2017

Juan Sun

2

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31 July 2017

Liqun Mao

3

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31 July 2017

Honggang Ye

4

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31 July 2017

Kenneth S Polonsky

5

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31 July 2017

language of work or name

English

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publication date

23 April 2014

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31 July 2017

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31 July 2017

63

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10

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31 July 2017

3378-3387

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describes a project that uses

31 July 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4171655/fullTextXML

inferred from PubMed Central ID database lookup

cites work

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

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PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells

5 July 2018

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USP18 is a key regulator of the interferon-driven gene network modulating pancreatic beta cell inflammation and apoptosis

5 July 2018

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PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.

5 July 2018

1 reference

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Expression of pro- and antiapoptotic molecules of the Bcl-2 family in human islets postisolation

5 July 2018

1 reference

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BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

5 July 2018

1 reference

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Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic β cell death and diabetes

5 July 2018

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Limitations in the Use of Fluorescein Diacetate/Propidium Iodide (FDA/PI) and Cell Permeable Nucleic Acid Stains for Viability Measurements of Isolated Islets of Langerhans

5 July 2018

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Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency

5 July 2018

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p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress

5 July 2018

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Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

5 July 2018

1 reference

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Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation

5 July 2018

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Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

5 July 2018

1 reference

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Bim regulates BCR-induced entry of B cells into the cell cycle

5 July 2018

1 reference

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Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis

5 July 2018

1 reference

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BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins

5 July 2018

1 reference

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Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

5 July 2018

1 reference

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Regulating insulin signaling and beta-cell function through IRS proteins

5 July 2018

1 reference

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Glucose regulates Foxo1 through insulin receptor signaling in the pancreatic islet beta-cell

5 July 2018

1 reference

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Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

5 July 2018

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FOXO transcription factors at the interface between longevity and tumor suppression

5 July 2018

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5 July 2018

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Phagocytosis-induced apoptosis in macrophages is mediated by up-regulation and activation of the Bcl-2 homology domain 3-only protein Bim.

5 July 2018

1 reference

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Susceptibility to apoptosis in insulin-like growth factor-I receptor-deficient brown adipocytes.

5 July 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

5 July 2018

1 reference

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

5 July 2018

1 reference

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Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

5 July 2018

1 reference

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The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Disruption of IRS-2 causes type 2 diabetes in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Critical roles of Bim in T cell activation and T cell-mediated autoimmune inflammation in mice

5 July 2018

1 reference

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Akt regulates the survival of vascular smooth muscle cells via inhibition of FoxO3a and GSK3.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171655

Cell Death in Development

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24760140

12 December 2020

inferred from PubMed ID database lookup

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24760140

12 December 2020

inferred from PubMed ID database lookup

Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24760140

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.2337/DB13-1814

1 reference

31 July 2017

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31 July 2017

1 reference